PI：吕忠显博士、教授、博士生导师   

个人简介：

福建省高等学校新世纪优秀人才。曾获厦门大学  “清源”、“鹭燕”科教奖。2006年担任加利福尼亚大学Irvine分校医学院助理研究员，2007年7月，以厦门大学“985”平台重点引进人才任厦门大学教授、代谢性疾病研究中心执行主任。目前是中国动物学会生殖生物学分会常务理事，北美生殖生物学、美国癌症研究协会、中国细胞生物学会、中国生理学会会员。现任代谢性疾病厦门市重点实验室主任、“生殖调控与生殖健康研究”福建省高校重点实验室副主任。

主要从事性腺发育与不孕不育、糖脂代谢疾病、肝癌及乳腺癌的基因调控研究，以发现和鉴别原创性分子治疗靶点，研发针对这些分子靶点的靶向药物。已在PNAS、J Mole Cell Biol、Oncogene、J BiolChem、Scientific Reports等国际一流杂志上发表多篇论文，并获得四项发明专利。获得国家重大科学研究计划项目（科技部973计划）课题（2013CB945503、2010CB945004）、科技部重点研发计划重点专项课题（SQ2017YFSF080005-02）、国家自然科学基金（31671564、81470111、31171375、30772546）、福建省卫教联合公关项目、厦门市科技项目等多项课题资助。

目前主要研究方向：

1、代谢性疾病的分子机制及靶向药物研发

2、生殖器官的发育及疾病

3、肝癌的基因调控

近期主要科研论文  (*  corresponding author)

1.Jianghong  Cheng#, YanhongZhong#, Shuai Chen#, Yan Sun, Lantang Huang, YujiaKang, Baozhen  Chen, Gang Chen, Fengli Wang, YingpuTian, Wenjie Liu, Gen-ShengFeng, and  Zhongxian  Lu.*Gab2  mediates hepatocellular carcinogenesis by integrating multiple  signalingpathways. FASEB  J 2017  Aug 21doi: 10.1096/fj.201700120RR.

2.Hao  Ran#, Shuangbo Kong#，Shuang  Zhang#, JianghongCheng,ChanZhou，Bo  He，Qiliang  Xin, John P Lydon, Francesco J DeMayo, Gen-Sheng Feng,GuoliangXia,  ZhongxianLu*,  Chao Wang*, Haibin Wang*. Nuclear Shp2 directs normal  embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src  kinase.ProcNatlAcadSci  U S A.  2017,114(18):4816-4821May 2. doi: 10.1073/pnas.1700978114

3.Jin  Tao, Lianping Zheng，MinghuiMeng,  Yanli Li, Zhongxian  Lu*.  Shp2 suppresses the adipogenic differentiation of preadipocyte 3T3-L1 cells at  the early stage.Cell  Death Discovery,  2016, 2:16051; doi:10.1038

4.Shuai  Chen#, Yujia Kang#, Yanli Li, Jin Tao, Baozhen Chen, Gang Chen, Yang  Li,YingpuTian, Yinan Zhao, jianghong Cheng,Wenjie Liu, Gen-Sheng Feng*,  Zhongxian Lu*.  Deletion  of Gab2  in mice  protects against hepatic steatosis and steatohepatitis: a novel therapeutic  target for fatty liver diseases.Journal  of Molecular Cell Biology，2016,  8(6), 492–504

5.Xiaopeng  Hu#, Zhenzhou Tang#, Yang Li#, Wensheng Liu, Shuang Zhang, Bingyan Wang,  YingpuTian, Yinan Zhao, Hao Ran, Wenjie Liu, Gen-Sheng Feng, Martin M. Matzuk,  JianweiShuai , Haibin Wang*，Zhongxian  Lu*.  Deletion  of the tyrosine phosphatase Shp2 inSertoli  cells causes infertility in mice. Scientific  Reports, 2015  Aug 12;5:12982. doi: 10.1038/srep12982

6.Xuan  Zhuang#, Zhiming Li#, Huinuan Lin, Long Gu, Qing Lin, Zhongxian  Lu*,  and Chi-mengTzeng*.  Integrated miRNA and mRNA expression profiling to identify mRNA targets of  dysregulatedmiRNAs in non-obstructive azoospermia.Scientific  Reports,  2015, Jan 28;5:7922. doi: 10.1038/srep07922

7.Wenqing  Huang#, Qing Lin#, Xuan Zhuang, LiangliangCai, RunshengRuan, Zhongxian  Lu*,  ChingmengTzeng*.Structure,Function,  and Pathogenesis of SHP2 in Developmental  Disorders and Tumorigenesis. Current  Cancer Drug Targets.  2014，14(6):567-88

8.Jun  Li#, Yujia Kang#, Longgang Wei, Wenjie Liu, YingpuTian, Baozhen Chen,  Xiandonglin, Yang Li, Gensheng Feng, Zhongxian  Lu*.Tyrosine phosphatase  Shp2 mediates the estrogen biological action in breast cancer via interaction  with the estrogen extranuclear receptor.  Plos  One, 2014;  9(7):e102847

9.Suman  Verma#,Michael  L. Salmans#,  Mikhail  Geyfman,  Hong  Wang,  Zhengquan  Yu,  Zhongxian  Lu,  Fang  Zhao,  Steven  M. Lipkin,  Bogi  Andersen*.  The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and  facilitates lobuloalveolar development. Developmental  Biology, 2012,  369(2):249-60

10.Jie  Wu#, Chi Wang#, Xilan Li, Yanling Song, Wei Wang, Cong Li, Jia Hu, Zhi Zhu,  Jiuxing Li,Weiyun Zhang, Zhongxian  Lu*  and Chaoyong James Yang*. Identification, Characterization and Application of a  G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior  Gradient Homolog 2. Plos  One, 2012,  7(9):e46393. doi: 10.1371

11.Dongping Liu#,Guiping  Kong#,QuanChengChen,Guanghui  Wang,Jie Li,Yang Xu, Ting lin, YingpuTian, Xiaokun Zhang, Xinsheng Yao, Gensheng  Feng, Zhongxian  Lu*and  Haifeng Chen*. Fatty acids asnatural  specific inhibitors of the proto-oncogenic protein Shp2.Bioorganic  & Medicinal Chemistry Letters,  2011，21:6833-6837.

12.Jia  Hu, Jie Wu, Cong Li, Ling Zhu, Weiyun Zhang,Guiping Kong，Zhongxian  Lu*,Chaoyong  Yang*. A G-aquadruplexaptamer inhibits  the phosphatase activity of oncogenic protein shp2.  Chembiochem, 2011,  12(3):424-30.

13.Yanyan  Bu#, Tao Shi#, MinghuiMeng#, Guiping Kong, YingpuTian,Quancheng Chen, Gensheng  Feng, Xinsheng Yao,Haifeng Chen* and  Zhongxian  Lu*.  A novel screening model for molecular drug for diabetes and obesity based on the  tyrosine phosphatase Shp2. Bioorganic  & Medicinal Chemistry Letters 2011，21:  874-878

14.YingpuTian#,  Ning Wang# and Zhongxian  Lu*.  Repression  of Lmo4 activated transcription inhibits proliferation and induces apoptosis of  normal mammary epithelial cells and breast cancer cells.Clinical  & Experimental Metastasis， 2010，27（7）：455-463

招聘：欢迎兴趣相投的助理教授、博士后、博士及硕士研究生加盟。

地址：福建省厦门市翔安区翔安南路厦门大学药学院 

邮编：361102

电话：0592-2187227

电子邮箱:zhongxian@xmu.edu.cn