郭慧玲 Guo Huiling, Ph.D.

助理教授

电话：13950085767

E-mail: ghuiling@xmu.edu.cn

2006年，毕业于东北师范大学生物科学专业，获理学学士学位

2012年，毕业于厦门大学生物化学与分子生物学专业，获博士学位

2012年-2015年，厦门大学附属中山医院，博士后

2015年3月-至今，厦门大学生命科学学院，助理教授

2006, B.S.,Northeast Normal University;

2012, Ph.D., Xiamen University;

2012-2015, Postdoctoral Fellow at Zhongshan Hospital, Xiamen University;

2015/03-present, Assistant Professor, School of Life Sciences, Xiamen University

研究领域(Research Area)

细胞代谢及其信号调控

代表性论文（Selected Publications）

1. Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Cell Res., 2015, 25(9):1025-1042.

2. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, LiangY, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY,Lin SC*. The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism. Cell Metab. 2014 20(3):526-540

3. Zhang YL, Guo HL, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, LianG, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC*. AMP as alow-energy charge signal autonomously initiates assembly of

AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab.18(4):546-555, 2013. (Co-first author)

4. Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z,Lin SY, Lin SC. TheAxin/TNKS complex interacts with KIF3A and isrequired for insulin-stimulated GLUT4 translocation. Cell Res.22: 1246-1257,2012.

5. Li Q, Lin SY., Wang X, Lian, G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J,Lin SC*. Axin determines cell fate by controlling the p53 activationthreshold after DNA damage. Nat. Cell. Biol. 11, 1128-1135, 2009.