莫萍丽，博士

副教授

电话：86-592-2182083

Email: mop@xmu.edu.cn

教育经历:

1996.09-2000.06   广西大学     学士 

2000.09-2003.06   广西大学     硕士

2003.09-2006.06   厦门大学     博士    

工作经历:

2006.10-2007.12  上海生化细胞所           博士后

2010.01-2010.12   美国Albany Medical Center   博士后   

2011.02-至今     厦门大学生命科学学院       副教授

研究领域（Research Area)

癌症是死亡率最高的疾病。虽然近年来，肿瘤的筛查、诊断以及治疗都有很大的进步，但是肿瘤的发病机制仍不十分清楚。 有许多的研究表明，肿瘤的发生发展跟多条信号通路的异常有关，例如WNT, NOTCH, p53, DNA损伤修复，PI3K等。因此，我们的研究兴趣主要在揭示这些信号通路在肿瘤的发生发展中的作用，为将来肿瘤的靶向治疗提供理论依据。

代表性论文(Selected Publications) 

1.Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C.Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression.J Immunol.2017 Jan 4.pii: 1600300. doi: 10.4049/jimmunol.1600300

2.Majaz S, Tong Z, Peng K, Wang W, Ren W, Li M, Liu K, Mo P, Li W, Yu C. Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression. Cell Biosci.2016 2; 6:47.doi: 10.1186/s13578-016-0114-6 

3.Li M, Wang W, Dan Y, Tong Z, Chen W, Qin L, Liu K, Li W, Mo P*, Yu C*. Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma.(* Co-Corresponding Author). 2016 May 17;7(20):29605-19

4.Tong Z, Li M, Wang W, Mo P, Yu L, Liu K, Ren W, Li W, Zhang H, Xu J, Yu C. Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/β-Catenin Signaling. J Biol Chem. 2015 Jul 24; 290(30):18596-608 

5.Mo P, Zhou Q, Guan L, Wang Y, Wang W, Miao M, Tong Z, Li M, Majaz S, Liu Y, Su G, Xu J, Yu C. Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene. 2015 Jul 23;34(30):3935-45

6.Xia X, Wan W, Chen Q, Liu K, Majaz S, Mo P, Xu J, Yu C. Deficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice. Cell Biosci.2014 Apr 23; 4:21.

7.Xia XC, Chen Q, Liu K, Mo PL, Zhu JW, Zhuang MQ, Shen YM, Yu CD. Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice. IntImmunopharmacol. 2013 Oct;17(2):336-41 

8.Zhu J, Chen Q, Xia X, Mo P, Shen Y, Yu C. Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice. ApplMicrobiolBiotechnol. 2013 Jan; 97(2):767-74

9.Mo P, Wang H, Lu H, Boyd D, Yan C. MDM2 mediates ubiquitination and      degradation of activating transcription factor 3.J. Biol. Chem. 2010 285, 26908-26915

10.Wang H*, Mo P*, Ren S, Yan C.Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. (*Equal contribution). J. Biol. Chem. 2010 285: 13201-13210

11.Mo P, Zhu Y, Liu X,Wang D.  Identification of two phosphatidylinositol /phosphatidylcholine transfer proteins that are predominately transcribed in the flowers of Arabidopsis thaliana. Journal of Plant Physiology, 2007, 4: 478-486

12.  Mo P, Yan C, Li Y, Qin G.  Research Progress of phosphatidylinositol / phosphatidylcholine transfer proteins. Chinese Journal of Cell Biology, 2007, 2:213-218