何承勇CHENGYONG HE, Ph.D.
副教授/硕士生导师(厦门大学生命科学学院)
理学博士 (厦门大学生命科学学院)
电话：0592-2187353
Email：hecy@xmu.edu.cn
2003/09-2007/06，南京农业大学，无锡渔业学院，本科
2007/09–2009/09，厦门大学，生命科学学院，硕士研究生
2011/09–2012/08，Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, USA国家留学基金委公派联合培养博士
2009/09–2012/12，厦门大学，生命科学学院生物学系，博士
2013/01–2017/07，厦门大学，公共卫生学院预防医学系，助理教授
2017/08–2018/07，厦门大学，公共卫生学院预防医学系，副教授
2018/08–至今，厦门大学，生命科学学院生物学系，副教授
研究方向
环境毒理学；纳米毒理学
主要研究内容
1.有机污染物发育毒性及分子机制；
2. 纳米材料生物安全性评价及毒性分子机制；
3. 内分泌干扰物生殖发育毒性
主持和参与科研课题：
1. 厦门大学校长基金，20720180045，未折叠蛋白反应ATF4通路调控内质网自噬介导量子点肾损伤机制研究与应用，2018/1-2020/12，在研，主持
2. 国家自然科学基金青年项目，81402648，多环芳烃通过NO介导的亚硝基化影响海马神经发育的机制研究，2015/01-2017/12，已结题，主持
3. 福建省中青年教师教育科研项目(A类)(福建省教育厅科技项目)，JA14004，苯并芘经NO介导蛋白亚硝基化影响海马神经发育的机制，2015/1-2017/5，已结题，主持
4. 厦门大学基本科研业务费，多环芳烃代谢调控影响神经细胞毒性的分子机制研究，2014，已结题，主持
5. 国家自然科学基金面上项目，81773465，环氧合酶2蛋白质稳态调控线粒体偶联的内质网功能介导肝毒性的机制研究，2018/01-2021/12，在研，参加，第二
6. 国家自然科学基金面上项目，81673129，耐铬菌株中还原酶介导环境铬(VI)降解及其诱导小鼠肝细胞功能的机制研究，2017/01-2020/12，在研，参加，第二
7. 国家自然科学基金面上项目，21577113，多氯联苯诱导糖尿病发生发展的过程及机理研究，2016/01-2019/12，参加，第二
8. 国家自然科学基金面上项目，81573181，PP2A介导抑癌蛋白转录非依赖性通路对外源物诱导线粒体质量控制的调控，2016/01-2019/12，在研，参加，第二
9. 福建省自然科学基金项目，2015J01344，AFB1诱导肝细胞坏死性凋亡的线粒体自噬信号通路调控机制研究，2015/04-2018/04，在研，参加
10. 国家自然科学基金面上项目，81472997，靶向蛋白磷酸酶2A信号调控是AFB1和HBx协同诱导肝毒性的一条新通路，2015/01-2018/12，在研，参与11. 973计划前期研究专项，2014CB560710，微生物致癌因子诱导细胞恶性转化的分子机制研究，2014/10-2016/10，已结题，参加，第四
12. 国家自然科学基金面上项目，20977071，不同环数的多环芳烃对海洋鱼类早期骨骼发育的影响及其分子机制，2010/01-2012/12，已结题，参加
13. 国家科技支撑计划，2007BAC27B02，POPs的机体负荷与健康效应评价技术研发，2008.1-2012.12，已结题，参加
主持教学改革项目：
厦门大学，《第三学期本科生系列学术沙龙的探索与实践》，2017/06-2019/10
指导大创课题：多项大创课题，其中2项国家级资助
发表的SCI论文
通讯作者文章：
1. Shengwei Jiang#, Yuchun Lin#, Huan Yao#, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu*, Zhongning Lin*, Chengyong He*. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitroand in vivo study.Archives of Toxicology. 2018;92(541) 1-14.(IF=5.728, JCR1区, 共通讯)
2. Bing Luo#, Yuchun Lin#, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu, Chengyong He*, Zhongning Lin*. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death & Disease.2016;7: e2251; doi:10.1038/cddis.2016.78 (IF=5.638, JCR2区, 共通讯)
第一作者文章：
3. Chengyong He#, Shengwei Jiang#, Haijing Jin#, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin*, Zhongning Lin*,Gang Liu*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016;83:102-114. (IF=8.557, JCR1区, 共一)
4.Chengyong He#, Shengwei Jiang#, Huan Yao#, Liyin Zhang, Chuanli Yang,Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin*, Yuchun Lin*, Xiaoyuan Chen. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomedicine. 2018 Sep 19. pii: S1549-9634(18)30521-5. (IF=6.5, JCR2区, 共一)
5. Chengyong He#, Shengwei Jiang#, Huan Yao#, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin*, Gang Liu*, Yuchun Lin*. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology. 2018, Accept. (IF=5.811, JCR1区, 共一)
6. Chengyong He#, Yang Qiu#, Peiyu Han#, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian-E Peng, Dong Liang, Xu Lin, Yuchun Lin*, Zhongning Lin*, and Ningshao Xia. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death & Disease. 2018. Jul 9;9(7):762. (IF= 5.638, JCR2区, 共一)
7. Mei Chen#, Shuzhen Chen#, Chengyong He#, Shiguang Mo, Xiaoyong Wang, Gang Liu*, and Nanfeng Zheng*, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging. Nano Research. 2017;10(4): 1234–1248. (IF=7.994, JCR1区, 共一)
8. Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang*, Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology. 2012:124-125C;28-33. (IF=3.761, JCR2区)
9. Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo*. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms. Aquatic Toxicology. 2012;116-117: 109-115. (IF=3.761, JCR2区)
10. Chengyong He,Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang*. Effects of Benzo(a)Pyrene on the skeletal development of Sebastiscus marmoratus embryos and the molecular mechanism involved. Aquatic Toxicology. 2011;101:335–341. (IF=3.761, JCR2区)
11.Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo*. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology. 2012; 33:758-762. (IF=3.096, JCR3区)
12.Chengyong He, Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo*. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2009; 154(2):221-228. (IF=1.923, JCR4区)
其他署名文章：
13. Duc-Viet Nguyen, Shengwei Jiang, Chengyong He, Zhongning Lin*, Naibo Lin, Anh-Tuan Nguyen, Lifeng Kang, Ming-Yong Han, and Xiang-Yang Liu* Elevating Biomedical Performance of ZnO/SiO2@Amorphous Calcium Phosphate-Bioinspiration Making Possible the Impossible.Advanced Functional Materials.2016;26: 6921–6929. (IF=12.124, JCR1区)
14. Teng-Jian Zhou, Shi-Li Zhang, Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Sheng-Wei Jiang, Huan Yao, Yi-Jun Huang, Wen-Hua Ling, Yu-Chun Lin *, Zhong-Ning Lin*. Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin related-protein 1. Theranostics. 2017;7(5):1389-06. (IF=8.712, JCR1区)
15. Kun Liao, Bin Xia, Qun-Ying Zhuang, Meng-Jun Hou, Yu-Jing Zhang, Bing Luo, Yang Qiu, Yan-Fang Gao, Xiao-Jie Li, Hui-Feng Chen, Wen-Hua Ling, Cheng-Yong He, Yi-Jun Huang, Yu-Chun Lin*, Zhong-Ning Lin*. Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway. Theranostics. 2015; 5(3):302-321. (IF=8.712, JCR1区)
16. Qunying Zhuang#, Tengjian Zhou#, Chengyong He, Shili Zhang, Yang Qiu, Bing Luo, Ran Zhao, Hengchuan Liu, Yuchun Lin* and Zhongning Lin*. Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b.Journal of Experimental & Clinical Cancer Research.2016;35:67 DOI 10.1186/s13046-016-0341-z. (IF=5.189, JCR2区)
17. Jiliang Zhang, Zhenghong Zuo, Chengyong He, Di Wu, Yixin Chen and Chonggang Wang*. Inhibition of thyroidal status related to depression of testicular development in Sebastiscus marmoratus exposed to tributyltin. Aquatic Toxicology. 2009;94(1): 62-67.(IF=3.761, JCR1区)
18. Shuzhen Chen#, Jun Zhang#, Shengwei Jiang, Gan Lin, Bing Luo, Huan Yao, Yuchun Lin, Chengyong He, Gang Liu* and Zhongning Lin* Self-Assembled Superparamagnetic Iron Oxide Nanoclusters for Universal Cell Labeling and MRI. Nanoscale Research Letter.2016 Dec;11(1):263.3. (IF= 2.833, JCR 2区)
19. Xiao Shi, Chengyong He, Zhenghong Zuo, Ruixia Li, Chen, Donglei Chen, Rong Wang, Chonggang Wang*, Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos. Marine Environmental Research. 2012;77:30-34. (IF=2.276, JCR3区)
20. Jiliang Zhang, Zhenghong Zuo, Chengyong He, Jiali Cai, Yuqing Wang, Yixin Chen and Chonggang Wang*. Effect of tributyltin on testicular development in Sebastiscus marmoratus and the mechanism involved. Environmental Toxicology and Chemistry.2009 Jul;28(7):1528-35. (IF=2.809, JCR3区)
21. Ruixia Li, Zhenghong Zuo, Denglei Chen, Chengyong He, Rong Chen, Yixin Chen, Chonggang Wang*. Inhibition by polycyclic aromatic hydrocarbons of ATPase activities in Sebastiscus marmoratus larvae: relationship with the development of early life stages. Marine Environmental Research. 2011;71(1): 86-90. (IF=2.276, JCR3区)
获奖：
1.2015.05厦门大学养生堂奖教金二等
2.2016.10中国毒理学会第五次中青年学者科技论坛优秀论文奖(口头汇报)
3. 2017.06四川美特生物奖教金一等
4. 2018.07 厦门大学公共卫生学院优秀党务工作者
地址：厦门大学翔安校区生命科学学院黄朝阳楼F214