陈航姿，博士 Chen Hang-zi, Ph.D.                                

教授，博士生导师

核受体与肿瘤代谢（Nuclear receptor and tumor metabolism）

E-mail: chenhz@xmu.edu.cn

1999-2003年, 厦门大学生命科学学院, 学士 

2003-2009年, 厦门大学生命科学学院, 博士

2005年, 新加坡国立大学生物科学系, 访问学生

2009-2012年, 厦门大学生命科学学院, 助理教授

2012-2018年, 厦门大学生命科学学院, 副教授

2018年至今, 厦门大学生命科学学院, 教授

1999-2003, School of Life Sciences, Xiamen University, Bachelor 

2003-2009, School of Life Sciences, Xiamen University,  Ph.D.

2005, Department of Biological Sciences, National University of Singapore, Visiting Students

2009-2012,School of Life Sciences, Xiamen University, Assistant Professor

2012-2018, School of Life Sciences, Xiamen University, Associate Professor

2018-present, School of Life Sciences, Xiamen University, Professor

研究领域（Research Area)

1.     围绕核受体的生物学功能开展研究，重点研究核受体在细胞生长、死亡等命运决定过程中的调控作用, 分析核受体与肿瘤、代谢综合症等疾病的相关性，并筛选靶向小分子化合物。

2.    关注肿瘤发生发展过程中代谢重编程的调控机制，重点探讨肿瘤如何感应代谢应激并通过核受体等关键节点蛋白的信号传递从而适应代谢应激的状态。

The main interest of our lab is the understanding of the biological effects of nuclear receptors, focusing on the regulatory roles of nuclear receptors in process of cell fate determination, the association of nuclear receptors with tumor and metabolic syndrome, and screening small molecular compounds that targeting to nuclear receptors.

We also interest in investigating the regulatory mechanisms of metabolic reprogramming during tumorigenesis, mainly discussing how tumor cells sense and adapt to metabolic stress.

代表性论文(Selected Publications) * Corresponding author  # co-first author

1.     Zhou B^#, Zhang JY^#, Liu XS^#, Chen HZ^#, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q*. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Research. 2018, 28(12):1171-1185.

2.    He JP^#, Hou PP^#, Chen QT^#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, 78(17):4853-4864.

3.     Li XX^#, Wang ZJ^#, Zheng Y^#, Guan YF^#, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q*, Chen HZ*. Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Molecular Cell. 2018, 69(3):480-492.

4.     Bian XL^#, Chen HZ^#, Yang PB^#, Li YP^#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420

5.     Li L^#, Liu Y^#, Chen HZ^#, Li FW^#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T*, Wu Q*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46.

6.    Wang WJ^#, Wang Y^#, Chen HZ^#, Xing YZ^#, Li FW^#, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann Friedrich, Wu M, Han J, Huang PQ, Lin T*, Wu Q*. Orphan nuclear receptor TR3 acts in autophagic cell death of melanoma via a mitochondrial signaling pathway. Nature Chemical Biology. 2014, 10:133-140. 

7.    Chen HZ*^#, Wen Q^#, Wang WJ, He JP, Wu Q. The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ. The International Journal of Biochemistry & Cell Biology, 2013, 45:1600 – 1609.

8.    Chen HZ, Li L, Wang WJ, Du XD, Wen Q, He JP, Zhao BX, Li GD, Zhou W, Xia Y, Yang QY, Hew C-L, Liou Y-C*, Wu Q*. Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene 2012, 31：2876-2887.

9.   Chen HZ^#, Liu QF^#, Li L^#, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY,  Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut 2012, 61：714-724.

10. Zhao BX^#, Chen HZ^#, Du XD, Luo J, He JP, Wang RH, Wang Y, Wu R, Hou RR, Hong M, Wu Q* Orphan Receptor TR3 Enhances p53 Transactivation and Represses DNA Double-Strand Break Repair in Hepatoma Cells under Ionizing Radiation. Molecular Endocrinology 2011, 25: 1337–1350.

11. Chen HZ, Zhao BX, Zhao WX, Li L, Zhang B, Wu Q*. Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis 2008; 29, 2078-2088.

12. Chen HZ, Wu Q*. A novel function of p53 in TR3-MDM2 cross-talk. Cell Res 2007; 17(4): 293-4.

荣誉、奖励及参加学术团体的情况（Honors and awards, Professional service）

2018年获国家优秀青年科学基金资助

Outstanding Youth Science Foundation

2017年福建省自然科学奖一等奖（排名第三）

First prize of Natural Science Award of Fujian Province (ranked the third)

2014年福建省青年拔尖创新人才

Youth Top-notch Talent in Fujian province

2012年福建省自然科学奖一等奖（排名第二）

First prize of Natural Science Award of Fujian Province (ranked the second)

中国病理生理学会肿瘤专业委员会青年委员

Youth member of the tumor professional committee ofChinese Association of Pathophysiology