余娴文 YU XIANWEN Ph.D

副教授  

Tel：2182609
E-MAIL：yuxw@xmu.edu.cn

1990-1994, 厦门大学生物学系微生物学专业，学士
1999-2005, 新加坡国立大学分子与细胞生物学研究院，博士

2005-2010, 新加坡科技研究局分子与细胞生物学研究院，博士后
1994, B.Sc., Xiamen University; 2005, Ph.D., Institute of Molecular and Cell Biology, National University of Singapore; 2005-2010, Research Fellow at the Institute of Molecular and Cell Biology, Agency of Science, Technology and Research (A*STAR) , Singapore; 2010-present, Associate Professor, School of Life Sciences, Xiamen University.

主要研究方向 (Research areas)：
越来越多的研究表明纤毛（Cilia），这一在生物进化过程中非常保守且分布广泛的细胞器，在细胞运动和信号传导过程中行使着重要的功能。纤毛在结构和功能上的异常会导致多种器官的疾病，统称为“纤毛相关疾病”。本人以斑马鱼（Zebrafish）为模式动物，深入研究调控纤毛发育，结构，及其功能的分子机制。这些研究将有助于更深入地理解人类“纤毛相关疾病”的发病机理，为“纤毛相关疾病”的诊断和治疗提供理论依据。
Cilia are evolutionarily conserved, microtubule-based cellular organelles in eukaryotes. With the increasing number of genetic diseases associated with ciliary dysfunctions identified over years, it becomes essentially important to study the ciliogenic program to elucidate the mechanisms of these ciliopathies. Currently, we are using zebrafish as a model system to further investigate the molecular mechanisms in the regulations of ciliogenesis. Our studies aim to provide the further understandings about the clinical features of ciliary dysfunctions.

代表性论文(Selected Publications)  *corresponding author

1.Yu X., Lau D., Ng C. P., Roy S. Cilia driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development 138： 487-494, 2011.
2.Tay S. Y., Yu X., Wong K. N., Panse P., Ng C. P., Roy S. The Iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Developmental Dynamics 239：527-34, 2010.
3.Yu X., Ng C. P., Habacher H., and Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics 40： 1445-1453, 2008.
4.Qiu W, Neo SP, Yu X, Cai M. A novel septin-associated protein, Syp1p, is required for normal cell cycle-dependent septin cytoskeleton dynamics in yeast. Genetics. Nov;180(3)：1445-57,2008
5.Xu, J., Srinivas, B. P., Tay, S. Y., Mak, A., Yu, X., Lee, S. G. P., Yang, H., Govindarajan, K. R., Leong, B., Bourque, G., Mathavan, S., and Roy, S. Genome-wide expression profiling in the zebrafish embryo indentifies target genes regulated by Hedgehog signalling during vertebrate development. Genetics 174, 735-752, 2006
6.Yu X., Cai M. The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p. J Cell Sci. 117, 3839-53, 2004
7.Zeng G, Yu X, Cai M. Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p. Mol Biol Cell. 12, 3759-72, 2001.