俞春东 YU Chundong, Ph. D.

教授，博士生导师

炎症与肝病学(Inflammation and Liver Diseases)

课题组组长

电  话: +86-0592-2182013

E-mail: cdyu@xmu.edu.cn 

1993年,中山大学生物学系生物化学专业，获理学学士学位；

1996年,厦门大学生物学系细胞生物学专业，获理学硕士学位；

2002年,美国德州大学休士顿健康科学中心细胞生物学专业，获博士学位；

2002年至2006年,美国贝勒医学院Bert O’Malley实验室,博士后研究工作；

2006至今,厦门大学生命科学学院教授，博士生导师，炎症与肝病学课题组组长。

Chundong Yu earned his B.S. degree in Biochemistry at Zhongshan University in 1993 and his M.S. degree in Cell Biology at Xiamen University in 1996.  He received his Ph.D. degree in Cell Biology at the University of Texas Health Science Center at Houston in 2002. He was a postdoctoral fellow in the laboratory of Dr. Bert O’Malley, Baylor College of Medicine from 2002-2006. He is a professor in the School of Life Sciences, Xiamen University.

研究领域 (Research Area)

  炎症与肝病学课题组主要从事生物医学的理论和应用基础研究。本课题组主要有两个研究方向：第一，研究核受体及其转录协同因子在炎症反应的发生、发展以及其在炎症反应相关疾病发病中的作用。第二，研究核受体及其转录协同因子在肝脏代谢及肝损伤、肝纤维化和肝癌等肝脏疾病发病中的作用。

Laboratory of Inflammation and Liver Diseases focuses on understanding the molecular basis of inflammation and liver diseases. The laboratory has two focuses: 1. To study the role of nuclear receptors and transcriptional coregulators in inflammation and inflammation-related diseases. 2. To study the role of nuclear receptors and transcriptional coregulators in liver metabolism and liver diseases such as liver injury, liver fibrosis and liver cancer.

代表性论文 (Selected Publications)

1.Wan W, Peng K, Li M, Qin L, Tong Z, Yan J, Shen B, Yu C*. Histone Demethylase JMJD1A Promotes Urinary Bladder Cancer Progression by Enhancing Glycolysis through Coactivation of Hypoxia Inducible Factor 1α. Oncogene 36: 3868–3877, 2017.

2.Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C*. Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression.The Journal of Immunology 198(4):1606-1615, 2017.

3.Tong Z, Li M, Wang W, Mo P, Yu L, Liu K, Ren W, Li W, Zhang H, Xu J, Yu C*. Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/beta-catenin Signaling.Journal of Biological Chemistry 290:18596-18608, 2015.

4.Mo P, Zhou Q, Guan L, Wang Y, Wang W, Miao M, Tong Z, Li M, Majaz S, Liu Y, Su G, Xu J, Yu C*. Amplified in Breast Cancer 1 Promotes Colorectal Cancer Progression Through Enhancing Notch Signaling. Oncogene 34:3935-3945, 2015.

5.Liu Y, Tong Z, Li T, Chen Q, Zhuo L, Li W, Wu R-C, Yu C*.Hepatitis B virus X Protein Stabilizes Amplified in Breast Cancer 1 Protein and Cooperates with It to Promote Human Hepatocellular Carcinoma Cell Invasiveness. Hepatology 56:1015-1024, 2012.

6.Chen Q, Li W, Wan Y, Xia X, Wu Q, Chen Y, Lai Z, Yu C*, Li W*. Amplified in Breast Cancer 1 Enhances Human Cholangiocarcinoma Growth and Chemoresistance by Simultaneous Activation of Akt and Nrf2 Pathways. Hepatology 55:1820-1829, 2012.

7.Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Yu C*. Steroid Receptor Coactivator 3 Is Required for CAR-regulated Hepatocyte Proliferation and Drug Metabolism. Journal of Hepatology 56:210-217, 2012.

8.Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, Xu J, Yu C*.Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-induced Septic Peritonitis. The Journal of Immunology 185: 5444-5452, 2010.

9.Xu Y, Chen Q, Li W, Su X, Chen T, Liu Y, Zhao Y, Yu C*.Overexpression of Transcriptional Coactivator AIB1 Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Proliferation and Invasiveness. Oncogene 29: 3386-3397, 2010.

10.Yu C, York B, Wang S, Feng Q, Xu J, O’Malley B. An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response. Molecular Cell 25: 765-778, 2007.

荣誉、奖励及参加学术团体的情况（Honors and awards, Professional service）

1.    2010年教育部新世纪优秀人才支持计划入选者

2.    2010年福建省自然科学基金杰出青年基金获得者