赵同金  ZHAOTong-Jin, Ph.D.

教授，博士生导师

课题组组长

E-mail：zhaotj@xmu.edu.cn

2002年，山东大学获学士学位

2007年，清华大学获博士学位

2007-2012年，美国西南医学中心博士后

2012-2014年，美国西南医学中心助理教授

2014至今，厦门大学教授

2002, B.Sc., Biochemistry and Molecular Biology, Shandong University;

2007, Ph.D., Biology, Tsinghua University;

2007-2012, Postdoctoral Fellow,UT Southwestern Medical Center, Dallas, Texas;

2012-2014,Assistant Professor, UT Southwestern Medical Center, Dallas, Texas;

2014-Present,Professor, School of Life Sciences, Xiamen University.

研究领域（Research Areas）

代谢紊乱已经越来越多的影响到人类的健康，其常见的几种表现形式主要有肥胖病、糖尿病和厌食症等。我们实验室的主要工作是要研究这些疾病的发病机制。我们的工作包括通过生物化学的手段来寻找新的饥饿和饱觉激素，通过细胞生物学的方法来研究这些激素的分泌，并且通过动物模型来研究这些激素在能量代谢中的作用。

In order to stay healthy, human bodies needto keep a perfect balance in energy metabolism. Imbalance in energy homeostasis will cause metabolic disorders, such as obesity, diabetes and anorexia nervosa.The focus of Zhao laboratory is to understand the underlying mechanism of these metabolic disorders. We will usebiochemical tools to identify new hormones that are involved in hunger and satiation, tissue culture to study regulation of hormone secretion, and mouse models to study physiological roles of thehunger and satiation hormones.

代表性论文（Selected Publications）

1.     McFarlane MR, Brown MS, Goldstein JL, Zhao TJ. (2014)Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet.Cell Metab. 2014 May 14. pii: S1550-4131(14)00171-5.

2.     Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ. (2012)Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J Biol Chem. 2012, 287: 17942-17950

3.   Zhao TJ, Sakata I, Li RL, Liang G, Richardson JA, Brown MS, Goldstein JL, Zigman JM. (2010) Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. ProcNatlAcadSci U S A. 36:15868-15873 (From the cover)

4.    Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS (2010) Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. ProcNatlAcadSci U S A. 107:7467-7472 (From the cover)

5.  Yang J, Zhao TJ, Goldstein JL, Brown MS. (2008) Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylatedpentapeptides. ProcNatlAcadSci U S A.:105:10750-10755. (Co-first author)

6.   Qi J, Gong J, Zhao TJ, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P. (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 27:1537-1548. (Co-first author)

7.   Zhao TJ, Yan YB, Liu Y, Zhou HM. (2007) The generation of oxidized form of creatine kinase is a negative control on muscle creatine kinase. J. Biol. Chem. 282: 12022-12029.

8.    Zhao TJ, Sun S, Liu Y, Liu JM, Liu Q, Yan YB, Zhou HM. (2006) Regulating the drought-responsive element (DRE)-mediated signaling pathway by synergic functions of trans-active and trans-inactive DRE binding factors in Brassica napus. J. Biol. Chem. 281: 10752-10759.

9.    Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB, Zhou HM. (2005) Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. J. Biol. Chem. 280: 13470-13476.