韩家淮 HAN Jiahuai, Ph.D.

教授，中国科学院院士,博士生导师

电  话：0592-2189390

E-mail:  jhan@xmu.edu.cn

实验室网址：http://hanlab.xmu.edu.cn/

                      (请访问实验室网站，获取最新信息）

1978-1982年，北京大学学士学位；

1982-1985年，北京大学硕士学位；

1990年，比利时布鲁塞尔大学，博士学位；

1990至1992年，美国德克萨斯大学西南医学中心博士后；

1993至2007年，历任美国Scripps研究所助理教授、副教授、教授；

2001年11至2007年7月，兼任厦门大学特聘教授；

2007年8月至今，厦门大学生命科学学院教授；

2013年12月，中国科学院院士；

厦门大学医学与生命科学学部主任； 

细胞应激生物学国家重点实验室主任；

厦门大学实验动物中心主任； 

厦门大学副校长。 

1978-1982, Beijing University (Peking University), China, B.S., Specialty in Biochemistry

1982-1985, Beijing University (Peking University), China, M. S., Specialty in Protein Chemistry

1985-1990, University of Brussels (Université Libre de Bruxelles), Belgium, 1990, Ph.D., Specialty in Molecular  Biology

1990-1992, Research Fellow, Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

1992-1993, Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, California,  USA

1993-1996, Assistant Member, Department of Immunology, The Scripps Research Institute, La Jolla, California,  USA

1996-2004, Associate Professor, Department of Immunology, The Scripps Research Institute,  La Jolla, California,  USA

 2004-2007, Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

 2002- 2007,  Adj. Professor, School of Life Sciences, Xiamen University, Xiamen, China

 2007 to present, Professor, School of Life Sciences, Xiamen University, Xiamen, China

 Dean, Faculty of Medicine and Life Sciences, Xiamen University, China

 Director, State Key Laboratory of Cellular Stress Biology

 Director,Innovation Center for Cell Signaling Network

 Director,Laboratory Animal Center,Xiamen University,China

 Vice President,Xiamen University,Xiamen,China 

研究领域(Research Area)

Dr. Jiahuai Han is known for the discovery of the p38 signaling pathway, one of the most important pathways in intracellular signaling transduction. This pathway plays important roles in many biological processes including cell cycle regulation, cell proliferation, cell differentiation and senescence, as well as immunity, development and tumorigenesis. Another current focus of Han lab is molecular mechanisms of programmed necrosis and the immune responseselicited. Han Lab is one of the laboratories that discovered the role of RIP3 and GSDMD in necroptosis and pyroptosis, respectively.

Han Lab is also interested in recognition and tolerance of invasive viruses and tumor cells.

The research in Han Lab will lead to a better understanding of the molecular mechanisms of tumorigenesis and host defense against foreign infections and sterile pathological changes, and thus provides new ideas for the development of therapeutic intervention for related diseases.

For more information, please visit our webpage: hanlab.xmu.edu.cn or https://scholar.google.com/citations?user=fgcjqnUAAAAJ&hl=zh-CN&oi=ao

代表性论文(Selected Publications)： 

1. He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 2015 Dec; 25(12): 1285-98.

2. Li Y, Zhong CQ, Xu X, Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S, Han J. Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files. Nat Methods. 2015 Oct 5;12(12):1105-6.

3. Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015; 17(4): 434-444.

4. Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J. RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice. Cell Host & Microbe. 2015 ; 17(2): 229-42.

5. Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2013; 24(1):105-21.

6. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. 2009. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science325: 332-6

7.  Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J. 2007. PRAK is essential for ras-induced senescence and tumor suppression. Cell128: 295-308

8. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J. 2005. Involvement of microRNA in AU-rich element-mediated mRNA instability.Cell120: 623-34

9. Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. 2002. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science295: 1291-4 

10. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature386: 296-9 

11. Han J, Lee JD, Bibbs L, Ulevitch RJ. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science265: 808-11