袁晶，YUAN JING, Ph.D.
闽江学者特聘教授，博士生导师
分子寄生虫学(Molecular Parasitology)
课题组长
E-mail：yuanjing@xmu.edu.cn

             http://yuanlab.xmu.edu.cn/

2002年7月，中国农业大学生物学院，学士学位；

2007年7月，中国农业大学生物学院，理学博士学位；

2007年10月至2012年10月，美国国立卫生研究院，博士后；

2012年10月至今，厦门大学生命科学学院教授，福建省闽江学者特聘教授。

2012年获美国国立卫生研究院院长奖（NIH Director’s Awards）;

2014年获863青年科学家资助。

2015年获国家自然基金优秀青年基金资助。

2002, B.S., China Agricultural University;

2007, Ph.D., China Agricultural University,

2007-2012, Postdoc, NIH, USA,

2012-present, Professor, School of Life Science, Xiamen University.

研究领域（Research Area)

疟疾仍然是全球最严重的传染性疾病之一，每年导致上亿的感染病例和上百万的死亡病例。疟疾疫苗的缺乏和疟疾寄生虫抗药株系的产生和传播为疟疾的全球防控带来巨大的挑战。本课题组的研究集中在两个部分：1. 以疟疾寄生虫恶性疟原虫为模型，研究抗药的分子和细胞机制；2. 以鼠疟寄生虫为模型，研究在寄生虫侵染宿主过程中，寄生虫因子与宿主因子及其互作.

Malaria remain one of most serious public health thread in the world, causing billions infection cases and millions death cases annually. Because of the lack of the effective vaccine and quick evolving and spreading globally of drug resistant parasite strains, we face the challenge for preventing and controlling malaria globally. Research in our group focus one two area: 1. Identify and characterize the genetic determinants conferring drug resistance in human malaria parasite, study the molecular and cellular mechanism regulating the drug resistance; 2. Based on the mouse malaria parasite model, investigate the signal pathway involved in the hepatocyte invasion and development of parasite sporozoite, we are particularly interested in identifying the host factors and their interaction with parasite factors during the parasite invasion and development in the host cell.

http://www.niaid.nih.gov/topics/malaria/understandingmalaria/Pages/default.aspx

http://www.niaid.nih.gov/topics/malaria/research/Pages/default.aspx

http://www.fightingmalaria.org/

代表性论文（Selected Publications，*Corresponding author）

1. Gao H^#, Yang Z^#, Wang X^#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*. ISP1-anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Current Biology. 2018; 28: 1-14.

2. Liu C^#, Li Z^#, Jiang Y, Cui H*, Yuan J*. Generation of Plasmodium yoelii malaria parasite carrying double fluorescence reporters in gametocytes. Mol Biochem Parasitol. 2018; 224: 37-43.

3. Qian P, Wang X, Yang Z, Li Z, Gao H, Su XZ, Cui H*, Yuan J*. A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing. Mol Biochem Parasitol. 2018; 222:21-28.

4. Zhang C^#, Li Z^#, Cui H^#, Jiang Y, Yang Z, Wang X, Gao H, Liu C, Zhang S, Su XZ*, Yuan J*. Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development. mBio. 2017; 8(6):e01986-17.

5. Zhang C^#, Gao H^#, Yang Z, Jiang Y, Li Z, Wang X, Xiao B, Su XZ, Cui H*, Yuan J*.  CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii. Mol Biochem Parasitol. 2016; 212:1-8.

6. Zhang C, Xiao B, Jiang Y, Zhao Y, Li Z, Gao H, Ling Y, Wei J, Li S, Lu M, Su XZ, Cui H*, Yuan J*. Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System. mBio. 2014; 5(4): 01414-14.

7. Yuan J^#, Cheng KC^#, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP*, Su XZ*. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science. 2011; 333:724-729. (Research article and Cover story; Rated “Exceptional” 10.0 by Faculty of 1000)

8. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology. 2009; 5(10):765-771.