李博安 LI Bo’ an , Ph.D.
教授，博士生导师
发育与肿瘤细胞生物学（Developmental and Tumor Cell Biology）
课题组组长
电 话：+86-592-2181987
E-mai：bali@xmu.edu.cn
1986年，第四军医大学，医学学士学位；
1996年，上海肿瘤研究所，生物化学与分子生物学博士学位；
1998至2006年，德国和美国先后任博士后和高级研究员；
2006年1月至今，厦门大学生命科学学院，闽江学者特聘教授，博士生导师。
2012年至今，厦门大学生命科学学院副院长，分子诊断教育部工程研究中心副主任。
1986, B. Med. The Fourth Military Medical University;
1996, Ph.D. Shanghai Cancer Institute;
1998-1999, Postdoctoral Fellow, Max-Planck Institute for Biochemistry, Germany;
2000-2004, Postdoctoral Fellow, University of California Irvine;
2004-2006, Senior Researcher, University of California Irvine;
2006-Present, Professor, Xiamen University School of Life Sciences.
2012-Present, Deputy Dean, Xiamen University School of Life Sciences.
研究领域(Research Area)
wnt信号通路在正常组织发育和肿瘤形成过程中发挥重要作用。我们实验室的兴趣在于，研究该信号通路的主要组份与调节因子在正常以及应激条件下，对于肿瘤发生、发展和组织发育、代谢过程的影响；并以此为基础进行肿瘤、遗传性疾病、代谢性疾病分子标志物的筛选，建立分子诊断新方法、新技术，涉及到表观遗传学、干细胞生物学、分子诊断等生物学前沿领域。
The canonical Wnt signaling pathway plays a central role in normal development and tumorigenesis。We are particularly interested in studying the roles of Wnt signaling components and regulators in tissue development, metabolism, and tumorigenesis under the normal and stress conditions. Our research projects touch on the knowledge frontiers of epigenetics and stem cell biology.
代表性论文(Selected Publications) (* corresponding or first author):
1. Zhang R, Hong JJ, Yang Q, Ong CT, Li BA*, Liou YC*. Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells. Oncogene. 2018 Dec 12. doi: 10.1038/s41388-018-0615-3.
2. Xie YY, Mo CL, Cai YH, Wang WJ, Hong XX, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, and Li BA* . Pygo2 regulates adiposity and glucose homeostasis via β-Catenin-Axin2-GSK3β signaling pathway. Diabetes. 2018 Oct;67(10):1935-1948. doi: 10.2337/db17-1452.
3. Lin LY, Yang L, Zeng Q, Wang L, Chen ML, Zhao ZH, Ye GD, Luo QC, Lv PY, Guo QW, Li BA*, Cai JC*, Cai WY*. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer. Mol Cancer. 2018 Apr 24;17(1):84. doi: 10.1186/s12943-018-0834-9.
4. Cai W, Chen G, Luo Q, Liu J, Guo X, Zhang T, Ma F, Yuan L, Li BA*, Cai J*. PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells. Mol Cancer Ther. 2017 Jun;16(6):1187-1198.
5. Zheng Z, Zhang P, He G, Liao K, Wang Z, Pan J, Du K, Du J, Li BA*. Simultaneous detection of 45 fusion genes in leukemia by dual-color fluorescence real-time PCR. Int J Lab Hematol. 2017 Apr;39(2):175-184.
6. Wang ZH, Li Z, Hu M, Yang QJ, Yan S, Wu RS, Li BA*, Guo M*. Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1. Gene. 2017 Feb 5;600:1-8.
7. Cai WY, Lin LY, Hao H, Zhang SM, Ma F, Hong XX, Zhang H, Liu QF, Ye GD, Sun GB, Liu YJ, Li SN, Xie YY, Cai JC, and Li BA*. YAP-TEAD and HNF4α repress reciprocally to regulate hepatocarcinogenesis. Hepatology. 2017 Apr;65(4):1206-1221.
8. Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ*, and Li BA*. Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway. Oncogene, 2016.09.08，35（36）：4787-4797
9. Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, and Li BA*. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors. Gastroenterology. 2016 Mar;150(3):659-671.
10. Zhou W, Shi G, Zhang Q, Wu Q, Li B*, Zhang Z*. MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN). Cell Biosci. 2014 Oct 14;4(1):62. doi:10.1186/2045-3701-4-62. eCollection 2014.
11. Xu J, Ren G, Zhao DA, Li BA, Cai CF, Zhou Y, Luo XY. Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells. Oncol Rep. 2014 Nov;32(5):1947-56. doi: 10.3892/or.2014.3451. Epub 2014 Aug 29.
12. Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM, Li BA* .Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. J Cell Sci. 2013 Dec 15;126(Pt 24):5692-5703.
13. Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA*. Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion. J Cell Sci. 2013, Jul 1;126(Pt 13): 2877-2889.
14. Li BA*. A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. Acta Pharmacol Sin. 2012 Jan; 33(1):3-4.
15. Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling . GUT.2012; 61:714-724.
16. Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, Wei T, Zhang L, Yang M, Liu Q, Ye G, Cheng P, Dai X and Li BA*. Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol. Cell. Biol. 2010 Dec;30(24):5621-35.
17. Chen YY, Li BA*, Wang HD, Liu XY, Tan GW, Ma YH, Shen SH, Zhu HW, Wang ZX. The role of Pygopus 2 in rat glioma cell growth. Med Oncol. 2011 Jun; 28(2):631-40.
18. Wang ZX, Chen YY, Li BA*, Tan GW, Liu XY, Shen SH, Zhu HW, Wang HD. Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth.. J Neurooncol. 2010 Oct;100(1):31-41.
19. Sun P, Yuan Y, Li A, Li B, Dai X. Cytokeratin expression during mouse embryonic and early postnatal mammary gland development.HistochemCell Biol. 2010 Feb; 133(2):213-21.
20. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and Li BA*, Dai X*, Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009, 185,811-826.
21. Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X.Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol. 2008 Aug 15;320(2):446-55.
22.Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M.Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15;318(2):224-35.
23.Li B*, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis.2007 May; 45(5): 318-25
24. Tao P, Xu D, Lin S, Ouyang GL, Chang Y, Chen Q, Yuan Y, Zhuo X, Luo Q, Li J, Li B, Ruan L, Li Q, Li Z. Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines. Cancer Lett. 2007 Aug 8; 253(1):60-7.
25. Ye Y, Li B*. 1'S-1'-Acetoxychavicol acetate (ACA) isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 (HIV-1) by blocking Rev transport. Journal of general Virology. 2006; 87: 2047-2053.
26. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X.Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol. 2006 Apr 24; 173(2):253-64.
27. Mackay DR, Hu M, Li B, Rheaume C, Dai X. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Jan 16;48, 543-552.
28. Li B*., Nair, M., Mackay, DR., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, PE., Dai, X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005; 132, 1463-1473.
29. Yan, HX., Wang, HY., Zhang, R., Chen, L., Li B., Liu, SQ., Cao, HF., Qiu, XH., Shan, YF., Yan, ZH., Wu, HP., Tan, YX., Wu, MC. Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1.Hepatology. 2004; 40(3): 618-28.
30. Li B*., Mackay, DR., Ma, J., Dai, X. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004; 84(2): 398-405.
31. Li B*., Dai, Q., Li, L., Nair, M., Mackey, D., Dai, X. Ovol2, a Mammalian Homolog of Drosophila ovo: Gene Structure, Chromosomal Mapping, and Aberrant Expression in Blind-Sterile Mice. Genomics. 2002; 80(3):319
32. Li B*., Mackey, DR, Dai, Q., Li, TW., Nair M., Fallahi, M., Schonbaum, CP., Fantes, J., Mahowald, AP., Waterman, ML., Fuchs, E., Dai, X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci, U S A. 2002; 30;99(9):6064-9.