尤涵 YOU Han, Ph.D.
国家杰青，福建省高校领军人才，厦门大学特聘教授，博士生导师
课题组组长
E-mail: hyou@xmu.edu.cn
1999年，第四军医大学七年制本硕联读临床医疗专业，医学学士与硕士学位；
2002年7月，第四军医大学，博士学位；
2000年3月-2001年6月，波士顿大学生化系,访问学生；
2001年7月-2003年8月，麻省理工学院肿瘤研究中心，访问学者；
2003年9月-2007年7月，加拿大多伦多大学，博士后；
2007年8月-至今，厦门大学生命科学学院，教授、博士生导师；
2011年-至今，细胞应激生物学国家重点实验室副主任；
2017年获国家杰出青年科学基金资助
Fourth Military Medical University., PhD. 2002.
March 2000 - June 2001: Visiting student, Boston University School of Medicine.
June 2001 – August 2003: Visiting scholar, Massachusetts Institute of Technology.
September 2003- July 2007: Postdoc fellow, University of Toronto.
August 2007- present: Professor, School of Life Sciences, Xiamen University
研究领域 (Research Area)
近年主要关注PI3K/AKT/FoxO通路与表观遗传修饰机制的互话在肿瘤耐药/肿瘤转移中的功能。另外，我们还关注应激刺激如何调控细胞分化，细胞凋亡，细胞自噬等生命活动。
The main interest of the lab is the understanding of the reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms. We are particularly interested in investigating how these crosstalks controlling chemoresistance and cancer metastasis. In addition, we are also interested in characterizing key molecules and signaling networks regulating cell differentiation, apoptosis and autophagy.
代表性论文(Selected Publications)
1 . Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H*. Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis. J Clin Invest. 2017, 127(6):2159-2175
2. Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H*. FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling. Hepatology 2016, 63(6):1914-1927
3. Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H*. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.Autophagy 2015, 11(9):1623-1635.
4. Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H*.Chaperone-like protein p32 regulates ULK1 stability and autophagy. Cell Death Differ.,2015, 22(11):1812-1823.
5. Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H*.TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PNAS ., 2012, 109(51), pp 20937-20942.
6. Zhang YR, Xing Y, Zhang L, MeiY, Yamamoto K, Mak TW*,You H*.Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1. PNAS.,2012. 109(15), pp 5717-5722
7. MeiY, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO
8. Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H, You H, Dong MQ, Yuan Z. Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep. 2012,13:371-377
9. Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012;209(1):173-86.
10.Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski D,Zhang H*. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.PNAS.,2011, 108(10):4129-34.
11.MeiY, Zhang YR,Yamamoto K, Xie W, Mak TW*,You H*. FOXO