Education

1982, B.Sc., Xiamen University；

1985, M.Sc., Xiamen University;

1999, Ph.D., Tsinghua University, Biochemistry & molecular biology.

Professional Experience

2000-2002, Visiting Scholar, University of California, Berkeley U.S.A;

1982-Present, Lecturer (1986), Associate Professor (1992), Professor (1998), Xiamen University.

Research Area

Our research areas focus on the structure and function of enzyme, inhibition/inactivation kinetics, regulation mechanism of enzyme activity and enzyme gene clone. We have made progress in the design of tyrosinase inhibitors and elected to characterize a number of new tyrosinase inhibitors. We have synthesized a series of tyrosinase inhibitors, including thiosemicarbazone compounds, cysteine schiff base compounds, cinnamic acid derivatives, alkyl 3,4-dihydroxybenzoates esters. We not only study their inhibitory effects and kinetics, but also investigate them using in the fruit and vegetable preservation and insecticide application.

Selected Publications

1. Huang GF, Wu XB*, Bai LP, Liu K, Jiang LJ, Long MN,Chen QX*. Improved O2-tolerance in variants of a H2-evolving [NiFe]-hydrogenase from Klebsiella oxytoca HP1.FEBS Lett. 2015, 589(8): 910-8.

2. Gui-Li Huang1, Wei Zhang2, Hong-Yue Ren3, Xue-Ying Shen1,Qing-Xi Chen* and Dong-Yan Shen*. Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-kB pathways. Cancer Science. 2015, 106(11): 1515–1523.

3. Cui Y, Liang G, Hu YH, Shi Y, Cai YX, Gao HJ,Chen QX, Wang Q*. Alpha-substituted derivatives of cinnamaldehyde as tyrosinase inhibitors: inhibitory mechanism and molecular analysis. J. Agric. Food Chem. 2015, 63(2): 716–722.

4. Feng Yu^#, Yu-Long Jia^#, Hui-Fang Wang, Jing Zheng, Yi Cui, Xin-Yu Fang, Lin-Min Zhang, andQing-Xi Chen*. Synthesis of Triazole Schiff's Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity. PLoS One. 2015, 10(9): e0138578.

5. Wei Song, Ling Tian, Shan-Shan Li, Dong-Yan Shen,Qing-Xi Chen. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.FEBS Letters. 2014, 588(3): 422–428.

6. Zhizhen Pan, Lian Xu, Yujing Zhu, Huai Shi, Zheng Chen, Meichun Chen,Qingxi Chen*, Bo Liu*. Characterization of a new cry2Ab gene of Bacillus thuringiensis with high insecticidal activity against Plutella xylostella L.World Journal of Microbiology and Biotechnology. 2014, 30(10): 2655-2662.

7.Apoptosis Induced by Aqueous Extracts of Crocodile Bile in Human Heptacarcinoma SMMC-7721.Wei Song, Shan-Shan Li, Ping-ping Qiu, Dong-Yan Shen, Ling Tian, Qiu-Yan Zhang, Long-Xing Liao,Qing-Xi Chen*.Applied Biochemistry and Biotechnology. 2013, 170(1): 15-24.

8. Huang GL1, Luo Q, Rui G, Zhang W, Zhang QY,Chen QX, Shen DY*. Oncogenic Activity of Retinoic Acid Receptor γ Is Exhibited through Activation of the Akt/NF-κB and Wnt/β-Catenin Pathways in Cholangiocarcinoma.Mol Cell Biol. 2013, 33(17): 3416-25.

9. Huang QS, Xie XL, Liang G, Gong F, Wang Y, Wei XQ, Wang Q, Ji ZL,Chen QX*. The GH18 Family of Chitinases: their domain architectures, functions, and evolutions. Glycobiology. 22: 23-34, 2012. (*Corresponding author).

10. Chai WM, Shi Y, Feng HL, Qiu L, Zhou HC, Deng ZW, Yan CL, Chen QX*. NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from (Bojer ex Hook.) Raf. and their bioactivities. J Agric Food Chem. 2012, 60: 5013-5022.

11. Pan ZZ , Li HL , Yu XJ , Zuo QX , Zheng GX , Shi Y, Liu X, Lin YM , Liang G, Wang Q,Chen QX*. Synthesis and Antityrosinase Activities of Alkyl 3,4-Dihydroxybenzoates.J Agric Food Chem. 2011, 59: 6645-6649.

12. Zhang JP, Hu YH, Wang Q, Wang W, Wang Y, Yan JH, Chen QX*. Inhibitory kinetics of β-N-Acetyl-D-glucosaminidase from green crab (Scylla Serrata) by Zinc ion.J Agric Food Chem. 2010, 58: 8763-8767.

13. Huang QS, Yan JH, Tang JY, Tao YM，Xie XL, Wang Y, Wei XQ, Yan QH, Chen QX*. Cloning and tissue expressions of seven chitinase family genes in L. vannamei.Fish Shellfish Immunol. 2010, 29: 76-82.

14. Han P, Kang JH, Li HL, Hu SX, Lian HH, Qiu PP, Zhang J, Li WG,Chen QX*. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression.Biochem Biophys Res Commun. 2009, 385: 251-256.