Education

1999, MD M.Sc., Fourth Military MedicalUniversity;

2002, Ph.D., Fourth Military Medical University.

Professional Experience

2000 - 2001,Visiting student, Boston University School of Medicine;

2001- 2003, Visiting scholar, Massachusetts Institute of Technology;

2003 - 2007, Postdoc fellow, University of Toronto;

2007- present, Professor, School of Life Sciences, Xiamen University.

Research Area

The main interest of the lab is the understanding of the reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms. We are particularly interested in investigating how these crosstalks controlling chemoresistance and cancer metastasis. In addition, we are also interested in characterizing key molecules and signaling networks regulating cell differentiation, apoptosis and autophagy.

Selected Publications

1. Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H,You H^﹡. FoxO3 inactivation promotes human cholangiocarcinomatumorigenesis and chemoresistance via Keap1-Nrf2 signaling.Hepatology. 2016. DOI: 10.1002/hep.28496.

2. Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z,Han J, You H*.Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.Autophagy. 2015 Sep; 11(9),1623-35.

3.H Jiao, G-Q Su, W Dong, L Zhang, W Xie, L-m Yao, P Chen, Z-X Wang, Y-C Liou andH You*.  Chaperone-like protein p32 regulates ULK1 stability and autophagy.Cell Death Differ. 2015, Apr 24. doi: 10.1038/cdd.2015.34.

4. Zhang L, Mei Y, Fu N Y, Guan L, Xie W, Liu H H, Yu C D, Yin Z, Yu V C, andYou H*. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.Proc Natl Acad Sci USA. 2012 Dec; 109(51): 20937-20942,. (*corresponding author)

5. Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW,You H*. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.Proc Natl Acad Sci USA. 2012 April; 109(15): 5717-5722. (*corresponding author)

6. Mei Y, Wang Z, Zhang L, Zhang Y, Li X, Liu H, Ye J,You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci USA. 2012 March; 109(13): 4898-4903. (*corresponding author)

7. Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C,You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.J Exp Med. 2012 Jan 16;209(1): 173-86.

8. Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y,You H*, Kwiatkowski D, Zhang H*. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.Proc Natl Acad Sci U S A., 2011, 108(10): 4129-34. (*co-corresponding author)

9. Mei Y, Zhang YR,Yamamoto K, Xie W, Mak TW*,You H*. FOXO3a-dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation.Proc Natl Acad Sci U S A., 2009, 106(13): 5153-8. (*co-corresponding author)

10. Sci. Signal., EDITORS' CHOICE: Cell Survival In the Pink1 with FOXO3a. 2009, Vol. 2, Issue 65