Education

1993, B.Sc., Zhongshan University;

1996, M.Sc., Xiamen University;

2002, Ph.D., University of Texas Health Science Center, Houston.

Professional Experience

2002-2006, Postdoctoral Fellow, Baylor College of Medicine;

2006-Present, Professor, School of Life Sciences, Xiamen University.

Research Area

Laboratory of Inflammation and Liver Diseases focuses on understanding the molecular basis of inflammation and liver diseases. The laboratory has two focuses: 1. To study the role of nuclear receptors and transcriptional coregulators in inflammation and inflammation-related diseases. 2. To study the role of nuclear receptors and transcriptional coregulators in liver metabolism and liver diseases such as liver injury, liver fibrosis and liver cancer.

Selected Publications

1. Zhu, J., Chen, Q., Xia, X., Mo, P., Shen, Y.,Yu C.*. Mycoepoxydiene Suppresses RANKL-induced Osteoclast Differentiation And Reduces Ovariectomy-induced Bone Loss in Mice.Appl Microbiol Biotechnol. 97(2): 767-774, 2013.

2. Liu Y, Tong Z, Li T, Chen Q, Zhuo L, Li W, Wu R-C,Yu C*. Hepatitis B virus X Protein Stabilizes Amplified in Breast Cancer 1 Protein and Cooperates with It to Promote Human Hepatocellular Carcinoma Cell Invasiveness.Hepatology. 56:1015-1024, 2012.

3. Chen Q, Li W, Wan Y, Xia X, Wu Q, Chen Y, Lai Z,Yu C*, Li W*. Amplified in Breast Cancer 1 Enhances Human Cholangiocarcinoma Growth and Chemoresistance by Simultaneous Activation of Akt and Nrf2 Pathways.Hepatology. 55:1820-1829, 2012.

4. Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q,Yu C*. Steroid Receptor Coactivator 3 Is Required for CAR-regulated Hepatocyte Proliferation and Drug Metabolism.Journal of Hepatology. 56: 210-217, 2012.

5. Chen Q, Chen T, Li W, Zhang W, Zhu J, Li Y, Huang Y, Shen Y*,Yu C*. Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the Suppression of TRAF6 Polyubiquitination.PLoS One. 7:e44890, 2012.

6. Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, Xu J,Yu C*. Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-induced Septic Peritonitis.The Journal of Immunology. 185: 5444-5452, 2010.

7. Xu Y, Chen Q, Li W, Su X, Chen T, Liu Y, Zhao Y,Yu C*. Overexpression of Transcriptional Coactivator AIB1 Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Proliferation and Invasiveness.Oncogene. 29: 3386-3397, 2010.

8. Chen Q, Zhao Y, Cheng Z, Xu Y,Yu C*. Establishment of A Cell-based Assay for Examining the Expression of Tumor Necrosis Factor Alpha (TNF-alpha) Gene.Applied Microbiology and Biotechnology. 80: 357-363, 2008.

9.Yu C, York B, Wang S, Feng Q, Xu J, O’Malley B. An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response.Molecular Cell. 25: 765-778, 2007.