Education

1999 - 2003, B.Sc., School of Life Sciences, Xiamen University;

2003 - 2006, Ph.D., Department of Biochemistry, Hong Kong University of Science and Technology;

2006 - 2009, Ph.D., School of Life Sciences, Xiamen University.

Professional Experience

2009 - 2012, Assistant Professor, School of Life Sciences, Xiamen University;

2012 - persent, Associate Professor, School of Life Sciences, Xiamen University.

Research Area

The molecular and cellular mechanisms of stress responses of the cells, including DNA damage, nutrient deprivation or growth factor restriction induced cell death, autophagy and metabolic reprogramming.

Selected Publications

1. Ruan K, Ye F, Li C, Liou YC, Lin SC,Lin SY. PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation.PLoS One 2012 7: e49184.

2.Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC. Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy.Autophagy 2012 8: 1385-1386.

3. Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z,Lin SY, Lin SC. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.Cell Res. 2012 22: 1246-1257.

4.Lin SY*, Li TY*, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC. GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy.Science 2012 336: 477-481.

5. Li Q, He Y, Wei L, Wu X, Wu D,Lin S, Wang Z, Ye Z, Lin SC. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.Oncogene2011 30: 1194-1204.

6. Li Q*,Lin S*, Wang X*, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC. Axin determines cell fate by controlling the p53 activation threshold after DNA damage.Nat Cell Biol 2009 11: 1128-1134.

7.Lin S, Wang J, Ye Z, Ip NY, Lin SC. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5.FEBS Lett 2008 582: 1197-1202.

8. Rui Y, Xu Z, Xiong B, Cao Y,Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A, Lin SC. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.Dev Cell 2007 13: 268-282.

9. Luo W, Zou H, Jin L,Lin S, Li Q, Ye Z, Rui H, Lin SC. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions.J Biol Chem 2005 280: 5054-5060.

10. Rui Y, Xu Z,Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.EMBO J2004 23: 4583-4594.