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黄烯教授 博导
出处: 发布时间:2016-11-20 浏览次数:12

  

黄烯HUANG Xi, Ph.D.

教授 博士生导师

光信号转导(Light signal transduction in plants

课题组组长

电话+86-592-2880348

E-mailxihuang@xmu.edu.cn

 

2007年,北京师范大学生命科学学院,学士学位

2012年,北京生命科学研究所/北京师范大学,生物化学与分子生物学,博士学位

2009-2011年,耶鲁大学,分子细胞发育生物学系,访问博士生

2012-2014年,北京大学-耶鲁大学植物分子遗传及农业生物技术联合中心,博士后

2014-2015年,厦门大学生命科学学院,副教授,课题组组长

2015年至今, 厦门大学生命科学学院, 教授、课题组组长   

2015年,入选中组部“青年千人计划”、福建省“百人计划”

 

2007, B.Sc., Biotechnology, Beijing Normal University;

2012, Ph.D., Molecular Biology and Biochemistry, Joint Program by National Institute of Biological Sciences and Beijing Normal University;

2009-2011, Visiting Scholar, Department of Molecular, Cellular, and Developmental Biology,Yale University;

2012-2014, Postdoctoral Fellow, Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology;

2014-2015, Principal Investigator, Associate Professor, School of Life Sciences, Xiamen University

2015-present, Principal Investigator, Professor, School of Life Sciences, Xiamen University

  

研究领域(Research Area

Light is the most important environmental cue for plant growth and development.To cope with the changing light environments, plants have evolved the capacity to optimize their growth.Since 1970s, an increase in UV-B irradiation has occurred due to ozone depletion. From the historical pointof view, UV-B light is regarded as a damaging stimulus to plants. Yet, currently advanced scientificinvestigation has revealed that plants benefit from UV-B irradiation in terms of photomorphogenicdevelopment, secondary metabolism, photoprotection, antioxidative response and resistance to pest anddisease attack. Beyond the area of plant researches, UV-B photobiology has advanced the tool development that allowsthe optical control of spatiotemporal signaling events in mammalian cells. These facts raise the possibilities that UV-B-mediated responses can be exploited to facilitate sustainable crop production, environmental conservation, and protein engineering in medical applications. Our lab aims to elucidate the molecular andbiochemical mechanisms of the UV-B light-mediated plant development. Combinatory approaches ofbiochemistry, molecular genetics, cell biology and computer science will be applied to investigate molecularframework of UV-B signaling cascade and crosstalk between UV-B light signal and other environmentalsignal pathways.

作为地球上最重要的环境因子,光对生命体的发生与维持起到了决定性的作用。在自然界多样的光环境中,UV-B波段对动植物的生长发育具有深远的影响。上个世纪70年代以来,全球环境恶化引起臭氧层变薄而导致UV-B辐射增强,使得人们日益关注UV-B光对动植物生命活动的影响。最新研究发现,UV-B光在光形态建成、次级代谢、抗病虫害等方面有益于植物发育。一系列基于UV-B光生物学的分子工具也被开发出来用于对哺乳动物细胞中的信号转导进行时空特异性调控。结合UV-B光信号有利于植物发育的潜能发掘与机制研究匮乏的现状,本课题组以模式植物拟南芥与我国重要作物水稻为研究对象,综合利用生物化学、分子生物学、遗传学、细胞生物学、数学、信息学等交叉学科手段,探索UV-B光调控植物生长发育的信号转导机制,及其与其它环境因子交互作用的分子机理,将有助于推动光能源在农业生产与环境保护等基本社会活动中的可持续应用,亦为基于光生物学原理的生物医学研究提供新的工具与方法。

 


代表性论文(Selected Publications

1.Huang, X., Ouyang, X., Deng, X. W. (2014) Beyond repression of photomorphogenesis: role switching of COP/DET/FUS in light signaling.CurrOpin Plant Bio l21, 96-103.

2.Huang, X., Yang, P., Ouyang, X., Chen, L., Deng, X. W. (2014) Photoactivated UVR8-COP1 module determines photomorphogenic UV-B signaling output in Arabidopsis.PLoS Genet10, dio: 10.1371.

3. Ouyang, X.*,Huang, X.*, Jin, X., Chen, Z., Yang, P., Ge, H., Li, S and Deng, X. W. (2014).Coordinated photomorphogenic UV-B signaling network captured by mathematical modeling.Proc Natl Acad Sci USA 111, 11539-11544. (*equal contribution)

4. Huang, X., Ouyang, X., Yang, P., Lau, O. S., Chen, L., Wei, N., Deng, X. W. (2013) Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B.Proc Natl Acad Sci USA110, 16669-16674.

5.Huang, X., Ouyang, X., Yang, P., Lau, O. S., Li, G., Li, J., Chen, H., Deng, X. W. (2012) Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription induction in response to photomorphogenic UV-B light.Plant Cell24, 4590-4606.

6.Huang, X.#, Deng, X. W. (2013) Organization of protein complexes under photomorphogenic UV-B in Arabidopsis.Plant Signal Behav8, e27206. (#corresponding author)

7. Chen, H.*,Huang, X.*,Gusmaroli, G., Terzaghi, W., Lau, O. S., Yanagawa, Y., Zhang, Y., Li, J., Lee, J.H., Zhu, D., Deng, X.W. (2010) Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time.Plant Cell22, 108-123. (*equal contribution)

8. Zhao, J.*,Huang, X.*,Ouyang, X.*, Chen, W., Du, A., Zhu, L., Wang, S., Deng, X. W., Li, S. (2012) OsELF3-1, an ortholog of Arabidopsis EARLY FLOWERING 3 regulates rice circadian rhythm and photoperiodic flowering.PLoS One7, e43705. (*equal contribution)

9. Kim, S.H., Kim, H., Seo, K.I., Kim, S.H., Chung, S., Huang, X., Yang, P., Deng, X.W., Lee, J.H. (2014) DWD HYPERSENSITIVE TO UV-B 1 is negatively involved in UV-B mediated cellular responses in Arabidopsis.Plant MolBiol 6, 571-583.

10. Xu, D., Lin, F., Jiang, Y.,Huang, X., Li, J., Ling, J., Hettiarachchi, C., Tellgren-Roth, C., Holm, M., Deng, X. W. (2014) The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings.Plant Cell26, 1981-1991.

11. Xu, X., Paik, I., Zhu, L., Bu, Q.,Huang, X., Deng, X. W., Huq, E. (2014) PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis.Plant Cell26, 1992-2006.

12. Wu, D., Hu, Q., Yan, Z., Chen, W., Yan, C.,Huang, X., Zhang, J., Yang, P., Deng, H., Wang, J., Deng, X. W., Shi, Y. (2012) Structural basis of ultraviolet-B perception by UVR8.Nature 484, 214-219.

13. Lau, O.S.,Huang, X., Charron, J.B., Lee, J. H., Li, G., Deng, X. W. (2011) Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.Mol Cell43, 703-712.

14. Ouyang, X., Li, J., Li, G., Li, B., Chen, B., Shen, H.,Huang, X., Mo, X., Wan, X., Lin, R., Li, S., Wang, H., Deng, X. W. (2011) Genome-wide binding site analysis of FAR-RED ELONGATED HYPOCOTYL3 reveals its novel function in Arabidopsis development.Plant Cell23, 2514-2535.

15. Li, J., Li, G., Gao, S., Martinez, C., He, G., Zhou, Z.,Huang, X., Lee, J. H., Zhang, H., Shen, Y., Wang, H., Deng, X. W. (2010) Arabidopsis transcription factor ELONGATED HYPOCOTYL5 plays a role in the feedback regulation of phytochrome A signaling.Plant Cell22, 3634-3649.

16. Wang, F., Zhu, D.,Huang, X., Li, S., Gong, Y., Yao, Q., Fu, X., Fan, L. M., Deng, X. W. (2009) Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system.Plant Cell21, 2378-2390.

17. Xiang, Y.,Huang, X.,Wang, T., Zhang, Y., Liu, Q., Hussey, P. J., Ren, H. (2007) ACTIN BINDING PROTEIN 29 from Lilium pollen plays an important role in dynamic actin remodeling.Plant Cell19, 1930-1946.