教授 博士生导师
光信号转导（Light signal transduction in plants）
课题组组长
E-mail：xihuang@xmu.edu.cn
2007年，北京师范大学生命科学学院，学士学位
2012年，北京生命科学研究所/北京师范大学，生物化学与分子生物学，博士学位
2009-2011年，耶鲁大学，分子细胞发育生物学系，访问博士生
2012-2014年，北京大学-耶鲁大学植物分子遗传及农业生物技术联合中心，博士后
2014年至今，厦门大学生命科学学院，课题组组长
2017年，国家重点研发计划（青年科学家项目）首席科学家、厦门市首批杰出青年人才
2018年，福建省高校领军人才青年拔尖人才
2007, B.Sc., Biotechnology, Beijing Normal University
2012, Ph.D., Molecular Biology and Biochemistry, Joint Program by National Institute of Biological
Sciences and Beijing Normal University
2009-2011, Visiting Scholar, Department of Molecular, Cellular, and Developmental Biology, Yale
University
2012-2014, Postdoctoral Fellow, Peking-Yale Joint Center for Plant Molecular Genetics andAgro-Biotechnology
2014-present, Principal Investigator, School of Life Sciences, Xiamen University
研究领域（Research Area）
Light is the most important environmental cue for plant growth and development.To cope with the changing light environments, plants have evolved the capacity to optimize their growth.Since 1970s, an increase in UV-B irradiation has occurred due to ozone depletion. From the historical point of view, UV-B light is regarded as a damaging stimulus to plants. Yet, currently advanced scientificinvestigation has revealed that plants benefit from UV-B irradiation in terms of photomorphogenicdevelopment, secondary metabolism, photoprotection, antioxidative response and resistance to pest anddisease attack. Beyond the area of plant researches, UV-B photobiology has advanced the tool development that allowsthe optical control of spatiotemporal signaling events in mammalian cells. These facts raise the possibilities that UV-B-mediated responses can be exploited to facilitate sustainable crop production, environmental conservation, and protein engineering in medical applications. Our lab aims to elucidate the molecular andbiochemical mechanisms of the UV-B light-mediated plant development. Combinatory approaches ofbiochemistry, molecular genetics, cell biology and computer science will be applied to investigate molecularframework of UV-B signaling cascade and crosstalk between UV-B light signal and other environmentalsignal pathways.
光是影响动植物生命活动最重要的环境因子。上世纪70年代以来，臭氧层空洞导致UV-B辐射增强，对自然环境与人类活动带来深远影响。最新研究发现，UV-B光在光形态建成、次级代谢、抗病虫害等方面有益于植物发育。同时，UV-B光遗传学工具可用于动植物细胞中的信号转导调控。针对UV-B光能源研究与利用的不足，本课题组综合利用生物化学、分子生物学、遗传学、细胞生物学、数学、信息学等交叉学科手段，探索UV-B光调控的植物生长发育，及其与其它环境信号的整合，对光能源在环境与农业中的科学应用具有重大的指导意义。
代表性论文（Selected Publications）
通讯/第一作者论文：
1.Ren, H., Han, J., Yang, P., Mao, W., Liu, X., Qiu, L., Qian, C., Liu, Y., Chen, Z., Ouyang, X., Chen, X., Deng, X.W., Huang, X.# (2019) Two E3 ligases antagonistically regulate the UV-B response in Arabidopsis. Proc Natl Acad Sci USA doi.org/10.1073/pnas.1816268116 (#corresponding author)
2.Qian, C., Mao, W., Liu, Y., Ren, H., Lau, O.S., Ouyang, X., Huang, X.# (2016) Dual-source nuclear monomers of UV-B light receptor direct photomorphogenesis in Arabidopsis. Mol Plant 9 (12), 1671-1674. COVER STORY (#corresponding author)
3.Huang, X., Ouyang, X., Deng, X.W. (2014) Beyond repression of photomorphogenesis: role switching of COP/DET/FUS in light signaling. CurrOpin Plant Biol21, 96-103.
4.Huang, X., Yang, P., Ouyang, X., Chen, L., Deng, X.W. (2014) Photoactivated UVR8-COP1 module determines photomorphogenic UV-B signaling output in Arabidopsis.PLoS Genet 10, dio: 10 (3), e1004218.
5.Ouyang, X.*, Huang, X.*, Jin, X., Chen, Z., Yang, P., Ge, H., Li, S., Deng, X.W. (2014).Coordinated
photomorphogenic UV-B signaling network captured by mathematical modeling. Proc Natl Acad Sci USA 111 (31), 11539-11544. (*equal contribution)
6.Huang, X., Ouyang, X., Yang, P., Lau, O.S., Chen, L., Wei, N., Deng, X.W. (2013) Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Proc Natl Acad Sci USA 110 (41), 16669-16674.
7.Huang, X., Ouyang, X., Yang, P., Lau, O. S., Li, G., Li, J., Chen, H., Deng, X.W. (2012) Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription induction in response to photomorphogenic UV-B light. Plant Cell 24 (11), 4590-4606.
8.Huang, X.#, Deng, X.W. (2013) Organization of protein complexes under photomorphogenic UV-B in Arabidopsis. Plant Signal Behav 8 (12), e27206. (#corresponding author)
9.Chen, H.*, Huang, X.*, Gusmaroli, G., Terzaghi, W., Lau, O. S., Yanagawa, Y., Zhang, Y., Li, J., Lee, J.H., Zhu, D., Deng, X.W. (2010) Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell 22 (1), 108-123. (*equal contribution)
10.Zhao, J.*, Huang, X.*,Ouyang, X.*, Chen, W., Du, A., Zhu, L., Wang, S., Deng, X.W., Li, S. (2012) OsELF3-1, an ortholog of Arabidopsis EARLY FLOWERING 3 regulates rice circadian rhythm and photoperiodic flowering. PLoS One 7 (8), e43705. (*equal contribution)
合作作者论文：
1.Du, A., Tian, W., Wei, M., Yan, W., He, H., Zhou, D., Huang, X., Li, S., Ouyang X. (2017) The DTH8-Hd1 module mediates day-length-dependent regulation of rice flowering. Mol Plant 10 (7), 948-961.
2.Zhu, L., Bu, Q., Xu, X., Paik, I., Huang, X., Hoecker, U., Deng, X.W., Huq, E. (2015) CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1.Nat Commun 6 (7245), 1-10.
3.Kim, S.H., Kim, H., Seo, K.I., Kim, S.H., Chung, S., Huang, X., Yang, P., Deng, X.W., Lee, J.H. (2014) DWD HYPERSENSITIVE TO UV-B 1 is negatively involved in UV-B mediated cellular responses in Arabidopsis. Plant MolBiol 86 (6), 571-583.
4.Xu, D., Lin, F., Jiang, Y., Huang, X., Li, J., Ling, J., Hettiarachchi, C., Tellgren-Roth, C., Holm, M., Deng, X.W. (2014) The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings. Plant Cell 26 (5), 1981-1991.
5.Xu, X., Paik, I., Zhu, L., Bu, Q., Huang, X., Deng, X.W., Huq, E. (2014) PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis. Plant Cell 26 (5), 1992-2006.
6.Wu, D., Hu, Q., Yan, Z., Chen, W., Yan, C., Huang, X., Zhang, J., Yang, P., Deng, H., Wang, J., Deng, X.W., Shi, Y. (2012) Structural basis of ultraviolet-B perception by UVR8. Nature 484 (7393), 214-219.
7.Lau, O.S., Huang, X., Charron, J.B., Lee, J. H., Li, G., Deng, X.W. (2011) Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock. Mol Cell 43 (5), 703-712.
8.Ouyang, X., Li, J., Li, G., Li, B., Chen, B., Shen, H., Huang, X., Mo, X., Wan, X., Lin, R., Li, S., Wang, H., Deng, X.W. (2011) Genome-wide binding site analysis of FAR-RED ELONGATED HYPOCOTYL3 reveals its novel function in Arabidopsis development. Plant Cell 23 (7), 2514-2535.
9.Li, J., Li, G., Gao, S., Martinez, C., He, G., Zhou, Z., Huang, X., Lee, J. H., Zhang, H., Shen, Y., Wang, H., Deng, X.W. (2010) Arabidopsis transcription factor ELONGATED HYPOCOTYL5 plays a role in the feedback regulation of phytochrome A signaling. Plant Cell 22 (11), 3634-3649.
10.Wang, F., Zhu, D., Huang, X., Li, S., Gong, Y., Yao, Q., Fu, X., Fan, L. M., Deng, X.W. (2009) Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell 21 (8), 2378-2390.
11.Xiang, Y., Huang, X., Wang, T., Zhang, Y., Liu, Q., Hussey, P.J., Ren, H. (2007) ACTIN BINDING PROTEIN 29 from Lilium pollen plays an important role in dynamic actin remodeling. Plant Cell 19 (6), 1930-1946.