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陈清西教授 博导
出处: 发布时间:2016-12-18 浏览次数:133


陈清西教授陈清西  CHEN Qingxi, Ph.D

厦门大学特聘教授,博士生导师

分子酶学Molecular Enzymology

课题组组长

http://121.192.179.196/cqxlab

话:+86- 592-2185487

真:+86-592-2185487

E-mailchenqx@xmu.edu.cn

1982.1毕业厦门大学动物学专业,学士学位;

1985.1毕业厦门大学生物化学专业,硕士学位;

1999.7毕业清华大学生物化学与分子生物学专业,理学博士学位;

2000.12002.2在美国加州Berkeley大学工作2年。

1998年至今,厦门大学生命科学学院,教授;

1982, BSc., Xiamen University

1985, MSc., Xiamen University;

1999, Ph.D., Tsinghua University, Biochemistry & molecular biology;

2000-2002, Visiting Scholar, University of California, Berkeley U.S.A;

1982-Present: Xiamen University. Lecturer (1986), Associate Professor (1992), Professor (1998).


研究领域(Research Area

主要从事酶的结构与功能、酶作用动力学、抑制动力学、抑制作用机理及功能酶的基因克隆等研究;抗癌活性多肽的分离纯化及作用机理的研究;酪氨酸酶抑制剂的分子设计及作用机理与应用的研究;我们已合成系列的酪氨酸酶抑制剂,包括缩氨基硫脲化合物、半胱氨酸席夫碱化合物、肉桂酸衍生物、3.4-二羟基苯甲酸烷基酯等系列化合物,研究它们对酪氨酸酶的抑制效应及动力学,探讨它们在果蔬保鲜和生物杀虫中的应用。近5年发表研究论文83篇,其中SCI论文39篇(JCR一区16篇、二区7篇),申请9个专利,其中8个已获得证书.

Our research areas focus on the structure and function of enzyme, inhibition/inactivation kinetics, regulation mechanism of enzyme activity and enzyme gene clone. We have made progress in the design of tyrosinase inhibitors and elected to characterize a number of new tyrosinase inhibitors. We have synthesized a series of tyrosinase inhibitors, including thiosemicarbazone compounds, cysteine schiff base compounds, cinnamic acid derivatives, alkyl 3,4-dihydroxybenzoates esters. We not only study their inhibitory effects and kinetics, but also investigate them using in the fruit and vegetable preservation and insecticide application.


代表论文(Selected Publications

1.Han P, et al. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression. Biochemical and Biophysical Research Communications, 2009, 385, 251-256.

2.Huang Q S, et al. Inhibitory effects of methyl trans-cinnamate on mushroom tyrosinase and its antimicrobial activities.J. Agric Food Chem. 2009, 57, 2565-2569.

3.Zhu YJ, et al. Anti-tyrosinase and Antimicrobial Activities of trans-Cinnamaldehyde Thiosemicarbazone J. Agric Food Chem. 2009, 57: 5518-5523.

4.Xie X L, et al. Inhibitory Kinetics of Betaine on β-N-Acetyl-D-glucosaminidase from Prawn (Litopenaeus vannamei).J. Agric. Food Chem. 2010, 58, 3820–3824.

5.Zhang J P, et al. Inhibitory kinetics of β-N-Acetyl-D-glucosaminidase from green crab (Scylla Serrata) by Zinc ion.J. Agric. Food Chem. 2010, 58: 8763-8767.

6.Zhuang J X. et al. Irreversible Competitive Inhibitory Kinetics of Cardol Triene on Mushroom Tyrosinase. J. Agric. Food Chem.2010, 58: 12993-12998.

7.Tao Y M, et al. Purification and Properties of Endoglucanase from a Sugar Cane Bagasse Hydrolyzing Strain, Aspergillus glaucus XC9.  J. Agric. Food Chem, 2010, 586126-6130.

8.Huang Q S, et al. Cloning and tissue expressions of seven chitinase family genes in Litopenaeus vannamei. Fish & Shellfish Immunology.2010, 29: 76-82.

9.Han P, et al. Inhibitory effects of 4-chlorosalicylic acid on mushroom tyrosinase and its antimicrobial activities. Food Chem, 2008, 107: 797–803.

10.Qiu L, et al. Inhibitory Effects of α-cyano-4- hydroxycinnamic acid on the activity of Mushroom Tyrosinase.Food Chem, 2009, 112: 609-613.


荣誉、奖励及参加学术团体的情况(Honors and Awards, Professional service)

2003年入选教育部跨世纪人才,2009年被遴选为厦门大学特聘教授。现任中国生物化学与分子生物学学会理事;中国酶学专业委员会副主任;中国蛋白质专业委员会中国农业生物化学与分子生物学常务理事;福建省生物化学与分子生物学学会副理事长;厦门市生物化学与分子生物学副理事长兼秘书长;《厦门大学学报(自然科学版)》副主编、《中国生物化学与分子生物学学报》、《生命的化学》、《基因组学与应用生物学》编委。

2009年度福建省科学技术进步奖三等奖-“多酚氧化酶抑制剂用于新型生物农药的创制

2011年度福建省科技进步奖二等奖-“龙眼褐变致腐机理及微生物保鲜关键技术的研究与应用