刘敏 Liu Min，Ph.D.

助理教授

电话：+86-592-2184533

E-mail: minliu@xmu.edu.cn

1998/09－2002/07，厦门大学，生物科学系，学士

2002/09－2008/06，厦门大学，生命科学学院，博士

2009/03－2013/11，美国加州大学伯克利分校，分子与细胞生物学系，博士后

2014/04－至今，厦门大学，生命科学学院，助理教授

研究领域（Research Area)

基因转录相关事件及其生理病理的功能。基因转录相关事件主要包括基因转录的过程及调控、RNA剪辑、表观遗传与基因转录调控；我们主要关注转录正常情况下细胞生长、分化以及转录异常情况下肥胖、炎症和癌症等人类切身相关的疾病。目前课题组主要采用传统生物学（包括生物化学和细胞生物学）和当代生物学（即生物信息学）等技术手段进行相关研究。

代表性论文(Selected Publications)

1.Xiaodong Lu*, Xinxing Zhu*, You Li*, Min Liu*, Bin Yu, Yu Wang, Muhua Rao, Haiyang Yang, Kai Zhou, Yao Wang, Yanheng Chen, Meihua Chen, Songkuan Zhuang, Lin-Feng Chen#, Runzhong Liu# and Ruichuan Chen#. ¬Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Research. 2016 Aug 19;44(14):6853-67. (影响因子：9.202，JCR 1区)，被国际著名专家在线评论推荐网站Faculty 1000所推荐

2.Duchu Chen, Huiping Wang, Jude Juventus Aweya, Yanheng Chen, Meihua Chen, Xiaomeng Wu, Xiaonan Chen, Jing Lu, Ruichuan Chen, and Min Liu#. HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling. BioMed Research International. 2016;2016:5173205. (影响因子2.134，JCR 3区)

3.Liu M#, Li Y, Chen RC#. CaMKII: Do Not Work Too Hard in the Failing Heart. J. Pathol., 2015; 235(5):669-71. (影响因子: 7.381，JCR 1区)

4.Liu M, Hsu J, Chan CK, Li Z and Zhou Q. The Ubiquitin Ligase Siah1 Controls ELL2 Stability and Formation of Super Elongation Complexes to Modulate Gene Transcription. Mol. Cell, 2012; 46 (3): 1–10. (影响因子: 15.28，JCR 1区)

5.He N, Chan CK, Sobhian B, Chou S, Xue Y, Liu M, Alber T, Benkirane M, Zhou Q. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. P. Natl. Acad. Sci. USA, 2011; 108(36):E636-45.(影响因子: 9.681，JCR 1区)

6.He NH, Liu M, Hsu J, Xue YH, Chou S, Burlingame A, Krogan NJ, Alber T and Zhou Q. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol. Cell, 2010; 38 (3): 428-438.(影响因子: 14.608，JCR 1区)

7.Ouyang GL*, Liu M*, Ruan K, Song G, Mao YB and Bao SD. Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett., 2009; 281(2): 213-219. (影响因子: 3.504)

8.Chen RC*, Liu M*, Li H*, Xue YH, Ramey WN, He NH, Ai NP, Luo HH, Zhu Y, Zhou N and Zhou Q. PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev., 2008; 22(10): 1356-1368. (影响因子: 14.795，JCR 1区)

9.Bao S, Ouyang GL, Bai XF, Huang Z, Ma CY, Liu M, Shao R, Anderson RM, Rich JN, Wang XF.  Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339. (影响因子: 18.122，JCR 1区)