张永有Zhang Yongyou, Ph.D.

教授，博士生导师

肿瘤代谢与组织再生（Cancer Metabolism and Tissue Regeneration）

课题组组长

电话：+86-592-2880335

E-mail：yongyouzhang@xmu.edu.cn

2000年，厦门大学，学士学位

2003年，厦门大学，硕士学位

2008年，美国德州农工大学，博士学位

2009年-2015年，美国凯斯西储大学，医学院，博士后

2015年-2016年，美国凯斯西储大学，医学院，研究科学家

2016年至今，厦门大学生命科学学院，教授、课题组组长   

2016年，入选“闽江学者”特聘教授

2000, B.S., Xiamen University

2003, M.S., Xiamen University

2008, Ph.D., Texas A&M University, Health Science Center

2009-2015, Postdoctoral Fellow at School of Medicine, Case Western Reserve University

2015-2016, Research Scientist at School of Medicine, Case Western Reserve University

2016-present, Principal Investigator, Professor, School of Life Sciences, Xiamen University 

研究领域（Research Area）

本课题组将致力于研究组织微环境的细胞信号调控在组织再生、肿瘤发生中的作用。利用基因修饰、基因敲除、转基因、高通量表达谱分析等相关技术，以临床样本、细胞系、体外组织培养以及动物疾病模型为研究对象，深入阐明以前列腺素为代表的脂类小分子代谢及其相关调控信号通路在组织干细胞扩增、稳态维持、分化、以及肿瘤发生中的作用，为组织修复与再生、肿瘤诊断、以及靶向药物的开发提供模型和理论依据。

Our research will focus on the regulation of cell signaling in tissue microenvironment response to tissue regeneration and tumorigenesis. We will use the technologies of gene modification, gene knockout, and transgene and high-throughput gene expression profiling to study the metabolism of small lipid molecule, such as prostaglandins, in clinical samples, cell lines, in-vitro tissue culture and animal models of disease. We hope our studies will provide some theoretical insighttoward the tissue repair and regeneration, cancer diagnosis, and the molecular target for therapy.

代表性论文（Selected Publications）

1. Y.Zhang*, A, Desai*, S. Yan*g, K. Bae*, M.Antczak*, S.Fink*, S. Tiwari*, et al., Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration. Science. Jun 12;348(6240), 2015 (Research Article with Perspective Review).

2.S.Fink, D.DawsonY. Zhang, A Kresak, E. Lawrence, P. Yang P, Y. Chen, J. Barnholtz, J. Willis, L. Kopelovich L, S. Markowitz. Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2014 Dec 10  .

3. F. Yang, Y.Zhang, S.J. Ressler, M.M Ittmann, G.E. Ayala, T.D. Dang, F. Wang ,D.R. Rowley. FGFR1 is essential for prostate cancer progression and metastasis. Cancer Research. 73(12): 2013.

4. Lin, X, Y. Zhang, L. Liu,W.L. McKeehan, Y. Shen, S. Song, and F. Wang. FRS2a is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.  International Journal of Biological Sciences. 7: 1114-21. 2011.

5. D. Zhou*,Y. Zhang*,H.Wu, E. Barry, Y. Yi, E. Lawrence, D. Dawson J.E. Willis, S.D. Markowitz, F.D. Camargo and J. Avruch. The Mst1 and Mst2 kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yap overabundance. PNAS.104(46): 2011.(* Co-first author).

6. Y. Zhang, J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan, N.M. Greenberg, and F. Wang.  Role of epithelial cell fibroblast growth factor receptor substrate 2a in prostate development, regeneration and tumorigenesis. Development. 135(4):775-84, 2008  .

7. Y. Zhang, W.L. McKeehan, Y. Lin, J. Zhang, and F. Wang. FGFR1 tyrosine phosphorylation regulates binding of FRS2alpha but not FRS2beta to the receptor.   Molecular Endocrinology. 22(1):167-75, 2008.

8.  J. Zhang, Y. Lin, Y. Zhang,Y.Lan, C. Lin, A.M. Moon, R.J. Schwartz, J.M.  Martin, and F. Wang (2008). Frs2a deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 135(21):3611-3622, 2008.

9. V. D. Acevedo, R. D. Gangula, R. Li, Y. Zhang, F. Wang, G.E. Ayala, L.E. Peterson, M. Ittmann, and D.M. Spencer. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial to mesenchymal transition. Cancer Cell.12(6):559-571. 2007 .

10. Y. Lin , G. Liu , Y. Zhang , Y. Hu , K. Yu , C. Lin , K. McKeehan , J. Xuan , D. Ornitz , M.M. Shen , N.M. Greenberg , W.L. McKeehan , F. Wang. Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.Development: 134: 723-734, 2007.

11. Y. Zhang, Y. Lin, C. Bowles, and F. Wang. Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2, Journal of Biological Chemistry. 31:379(53), 2004.  

12. J. Cheng,Y. Zhang and Q. Li. Real-time PCR genotyping using displacing probes, Nucleic Acids Research: 32(7): e61. 2004 .