张亚霖 Zhang Yalin,Ph.D.

教授，博士生导师

代谢与疾病 (Metabolism and Diseases)

课题组长

E-mail: zhangyalin@xmu.edu.cn

2008年，厦门大学，生物科学专业，学士学位

2013年，厦门大学，生物化学与分子生物学专业，博士学位

2014-2018年，美国爱因斯坦医学院博士后

2018年至今，厦门大学生命科学学院教授

2008, B.Sc., Biological Sciences, Xiamen University

2013, Ph.D., Biochemistry and Molecular Biology, Xiamen University

2014-2018, Postdoctoral Fellow, Albert Einstein College of Medicine

2018-Present, Professor, School of Life Sciences, Xiamen University

研究领域

代谢紊乱与神经退行性疾病的发生发展密切相关。本课题组以中枢调控代谢的核心区域下丘脑为研究对象，利用代谢疾病模型，转基因和基因敲除小鼠模型等实验手段，研究糖代谢和脂肪代谢在神经退行性疾病中的调控作用。

Research Area

The prevalence of neurodegenerative disease rises along with extended lifespan over the last fifty years. It has been shown that metabolic dysfunction has a strong correlation with neurodegeneration. Our research group focuses on the role of hypothalamus, which is known as a key area in central nervous system modulating energy metabolism, in the regulation of neurodegenerative disease induced by disruption of homeostasis of glucose and lipid metabolism.

代表性论文(Selected Publications, # First author * Corresponding author)

1. Zhang Y, Kim MS, Jia B, Yan J, Zuniga-Hertz JP, Han C, Cai D. Hypothalamic stem cells    control aging speed partly through exosomal miRNAs. Nature. 2017 Aug 3;548(7665):52-57.

2. Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic process plasticity and  IKKβ/NF-κB in central control of blood glucose, blood pressure and body weight. Cell Metabolism. 2017 May 2;25(5):1091-1102.

3. Ale A, Zhang Y, Han C, Cai D. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. Am J Physiol Endocrinol Metab. 2016 Nov 15:ajpendo.00337.2016.

4. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature Immunology. 2015 May;16(5):525-33.

5. Zhang Y, Liu G, Yan J, Zhang Y, Li B, Cai D. Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. Nature Communications. 2015 Apr 7;6:6704.

6. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang Y, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism. 2014 Sep 2;20(3):526-40.

7. Zhang Y, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55.