袁立 YUAN Li, Ph.D.
教授，博士生导师
血管生物学(Vascular Biology)
课题组组长
电 话：+86-592-2182019
E-mail: yuanli@xmu.edu.cn
Lab website:http:// 210.34.20.18/yuanli
1982年,江西农业大学学士学位，
1988年,华中农业大学硕士学位，
2002年,法国居里大学博士学位；
1982年至1999年，江西农业大学教师；
1997年至2006年，法国科研中心与法兰西学院细胞与分子胚胎研究所、法兰西学院实验医学实验室访问学者、博士和博士后；
2006年至今，厦门大学教授。
1982, B. Sc, Jiangxi Agricultural University;
1988, M. Sc, Huazhong Agricultural University;
2002, Ph.D, University of Pierre-et-Marie-Curie.
1982-1989, Faculty member at Jiangxi Agricultural University;
1997-2006, Doctoral and postdoctoral fellow at Institute of Cellular and Molecular Embryology, Laboratory of Experimental Medicine to CNRS and to College of France in France;
2006-Present: Professor at School of Life Sciences, Xiamen University.
研究领域(Research Area)
主要从事组织器官发育的分子控制机制。我们之前的研究主要集中在血管及淋巴管系统的发育机制。我们揭示了动、静脉血管皮细胞发育分化的可塑性规律、血液动力学对动、静脉分化的作用，以及Angiopoitin-1/2、Tie1/2、NRP1/2 等分子在血管系统的表达、功能及其机作用机制，尤其是通过Netrin/Unc5B分子系统在血管中的表达与功能的研究，首次直接证实血管生长存在类似神经生长的导向机制,控制其布局与走向。我们致力于通过建立活体鸡胚核酸干扰技术，研究血管初始形成与血管新生中的细胞与分子机制，重点系统研究神经导向因子在正常血管系统发育与在肿瘤血管新生中的作用功能及其机制。最近，在国家重大科学研究计划的支持下，我们的研究拓展到了猪和鸡的骨胳肌与脂肪组织发育的分子机制，着重建立猪和鸡的骨胳肌与脂肪干细胞体系，研究其分化与组织形成的分子机制。
Our research lies in the area of mechanisms of development of tissue/organ systems. Previously our research was focused on the molecular mechanisms controlling vessel formation under normal and pathological settings. We have elucidated the plasticity of endothelial cells during arterial-venous differentiation and how blood flow could regulates arterial-venous differentiation in the avian embryo; and we have revealed the expression and functions of molecules such as Angiopoitin-1/2、Tie1/2、NRP1/2 in the vascular system. By reveal of the Netrin/Unc5B function in the vascular system, we have confirmed that the development of vascular system adapted the guidance mechanisms as the nervous system. We work on establishing chicken RNAi techniques and exploring further the molecular mechanisms in course of vasculogenesis and angiogenesis. In response to “The National Key Scientific Program of China”, we have recently extended our research area to molecular mechanisms controlling the development of muscle and adipose tissues in chicken and swine. We apply state-of-the-art approaches of cell and molecular biology to depict the molecular network controlling the developmental processes of the two major tissues in those animals.
代表性论文(Selected Publications)
1.Liu K, Wang H, Long Y, Ye J, Yuan L* Coordinate lentiviral expression of Cre recombinase and RFP/EGFP mediated by FMDV 2A and analysis of Cre activity. J Cell Biochem 113: 2909-19, 2012. (* correspondence author)
2.Li H, Xi Q, Xiong Y, Cheng X, Qi Q, Yang L, Shu G, Wang S, Wang L, Gao P, Zhu X, Jiang Q, Zhang Y,* Yuan L.* A comprehensive expression profile of micrornas in porcine pituitary.PLoS One 6 e24883, 2011 (* correspondence author)
3.Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G*. (2011). Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene 30(47): 4707-4720
4.Huang W, Liu H, Wang T, Zhang T, Kuang J, Luo Y, Chung SS, Yuan L, Yang JY *. Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high NaCl hypertonicity. Nucl Acids Res 39:475-85,2011
5.Liu H, Luo Y, Zhang T, Zhang Y, Wu Q, Yuan L, et al. Genetic Deficiency of Aldose Reductase Counteracts the Development of Diabetic Nephropathy in C57BL/6 Mice. Diabetologia 54:1242-51,2011
6.Xu Y*, Yuan L,* Mak J*, et al. Neuropilin-2 mediates VEGF-C induced lymphatic speouting together with VEGFR3. J Cell Biol. 188:115-30，2010. (* equal contribution)
7.Jones EA, Yuan L, Breant C, et al. separating genetic and hemodymamic defects in neuropilin-1 knockout embryos Development , 135: 2479-88, 2008
8.Bouvrée K, Larrivée B, Lv X, Yuan L, et al. Netrin-1 in hibits sprouting angiogenesis in developing avian embryos. Dev Biol. 318(1):172-83, 2008
9.Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, et al. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes & Dev. 21: 2433-7, 2007
10.Ye J and Yuan L * Inhibition of p38 MAPK reduces tumor conditioned medium-induced angiogenesis in co-cultured human umbilical vein endothelial cells and fibroblasts. Biosci Biotechnol Biochem 71: 1162-9, 2007.(* correspondence author)
11.Yuan L, Eichmann A, Corvol P. Neural guidance molecules in vascular development. Angiogenesis: Basic Science and Clinical Aspects. CRC press p89-110, 2007.
12.Eichmann A, Yuan L, Moyon D, LeNoble F, Pardanaud L, Bréant C. Vascular development : from precursor cells to branched arterial and venous networks. Int J Dev Biol. 49(2-3):259-67,2005
13.Lu X*, LeNoble F*, Yuan L*, et al. The netrin receptor Unc5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432:179-86, 2004. (* equal contribution)
14.eNoble F, Moyon D, Pardanaud L, Yuan L.， et al. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development. 131: 361-75, 2004.
15.Yuan L, Moyon D, Pardanaud L, Bréant C, Karkkainen MJ, Alitalo K, Eichmann A. Abnormal lymphatic vessel development in neuropilin-2 mutant mice. Development 129, 4797-4806, 2002.